The relationship between bone mineral density and periodontitis in postmenopausal women
The relationship between bone mineral density and periodontitis in postmenopausal women
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DOI：
10.1902/jop.2000.71.9.1492
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发表时间：
2000-09-01
影响因子：
4.3
通讯作者：
Genco, RJ
中科院分区：
文献类型：
--
作者：
Tezal, M;Wactawski-Wende, J;Genco, RJ
背景：全身性骨质流失被认为是牙周病的一个危险因素；然而，这两种疾病之间的关系尚不清楚。本研究的目的是评估全身骨密度和牙周病之间的关系，控制已知的混杂因素。方法：研究人群包括70名绝经后高加索妇女，年龄51 ~ 78岁（平均+/- SD: 62.10 +/- 7.1岁）。采用双能x线骨密度仪（DXA）评估颈部、粗隆、粗隆间、Ward三角区和股骨总区以及腰椎前后位的骨密度（BMD）。牙周病的严重程度表现为临床附着丧失（CAL）和近端牙槽间骨丧失（ABL）。其他牙周状况的测量包括探诊深度（PD）、龈上菌斑、探诊时牙龈出血和牙石。DXA和口腔检查由校准的检查员进行。通过调整年龄、绝经年龄、雌激素补充、吸烟、体重指数和龈上斑块等因素的多元线性回归分析获得偏相关系数(r)。结果：平均ABL与股骨粗隆骨密度（r = - 0.27）、Ward三角区骨密度（r = -0.26）、股骨总区域骨密度（r = -0.25）相关。平均CAL似乎在骨骼的所有区域都与BMD一致相关，尽管这种关联没有达到统计学意义。结论：我们可以得出结论，骨骼骨密度与近端牙槽间骨丢失有关，在较小程度上与临床附着丧失有关，这意味着绝经后骨质减少是绝经后高加索妇女牙周病的危险指标。
Background: Systemic bone loss has been proposed as a risk factor for periodontal disease; however, the relationship between these two diseases is still not clear. The objective of this study was to assess the relationship between systemic bone mineral density and periodontal disease, controlling for known confounders.Methods: The study population included 70 postmenopausal Caucasian women aged 51 to 78 (mean +/- SD: 62.10 +/- 7.1 years). Skeletal bone mineral density (BMD) was assessed by dual energy x-ray absorptiometry (DXA) at the neck, trochanter, intertrochanter, Ward's triangle, and total regions of the femur, and from the anterior-posterior view of the lumbar spine. Periodontal disease severity was represented by clinical attachment loss (CAL) and interproximal alveolar bone loss (ABL). Other measures of periodontal status included probing depth (PD), supragingival plaque, gingival bleeding on probing, and calculus. DXA and oral examinations were performed by calibrated examiners. Partial correlation coefficients (r) were obtained from multiple linear regression analysis adjusting for age, age at menopause, estrogen supplementation, cigarette smoking, body mass index, and supragingival plaque.Results: Mean ABL was significantly correlated with BMD of the trochanter (r = - 0.27), Ward's triangle (r = -0.26), and total regions of the femur (r = -0.25). Mean CAL appeared to be related to BMD consistently at all regions of the skeleton, although the association did not reach statistical significance.Conclusions: We can conclude that skeletal BMD is related to interproximal alveolar bone loss and, to a lesser extent, to clinical attachment loss, implicating postmenopausal osteopenia as a risk indicator for periodontal disease in postmenopausal Caucasian women.