A comprehensive analysis of the MAGE family as prognostic and diagnostic markers for hepatocellular carcinoma
A comprehensive analysis of the MAGE family as prognostic and diagnostic markers for hepatocellular carcinoma
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MAGE家族作为肝细胞癌预后和诊断标志物的综合分析
DOI：
10.1016/j.ygeno.2020.09.026
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发表时间：
2020-11-01
期刊：
影响因子：
4.4
通讯作者：
Jie, Yusheng
中科院分区：
文献类型：
--
作者：
Li, Rong;Gong, Jiao;Jie, Yusheng
黑色素瘤抗原基因（法师）家族是一个大的、高度保守的蛋白质组，据报道其参与人类多种癌症的进展。然而，不同的法师基因在肝细胞癌（HCC）的功能在很大程度上是不清楚的。本研究对MAGEs在肝癌中的表达、临床意义、基因改变、相互作用网络和功能富集等方面进行了综合评价。我们的研究表明，在肝癌中，许多法师基因表达异常。其中MAGEA1、MAGEC2、MAGED1、MAGED2、MAGEF1和MAGEL2与HCC的临床分期和分化程度显著相关。MAGED 1、MAGED 2、MAGEA 6、MAGEA 12、MAGEA 10、MAGEB 4、MAGEL 2和MAGEC 3与HCC预后显著相关。进一步的功能富集分析表明，MAGEs表达异常可能在信号转导中起重要作用。这些结果表明，多个异常MAGE可能在HCC的发展中发挥重要作用，并可作为有用的生物标志物用于HCC的诊断和治疗。
The Melanoma Antigen Gene (MAGE) family is a large, highly conserved group of proteins which was reported to participate in the progression of multiple cancers in humans. However, the function of distinct MAGE genes in hepatocellular carcinoma (HCC) is largely unclear. In this study, we comprehensively evaluated the expression, clinical significance, genetic alteration, interaction network and functional enrichment of MAGEs in HCC. Our research showed that many MAGE genes were dysregulated in HCC. Among them, MAGEA1, MAGEC2, MAGED1, MAGED2, MAGEF1 and MAGEL2 were significantly associated with clinical stage and differentiation of HCC. MAGED1, MAGED2, MAGEA6, MAGEA12, MAGEA10, MAGEB4, MAGEL2 and MAGEC3 significantly correlated with HCC prognosis. Further functional enrichment analysis suggested the dysregulated MAGEs may play important roles in signal transduction. These results indicate that multiple dysregulated MAGEs might play important roles in the development of HCC and can be exploited as useful biomarkers for diagnosis and treatment in HCC.