Pain Hypervigilance is Associated with Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity Among Adults with Symptomatic Knee Osteoarthritis
Pain Hypervigilance is Associated with Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity Among Adults with Symptomatic Knee Osteoarthritis
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DOI：
10.1007/s12160-013-9563-x
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发表时间：
2014-08-01
影响因子：
3.8
通讯作者：
Fillingim, Roger B.
中科院分区：
文献类型：
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作者：
Herbert, Matthew S.;Goodin, Burel R.;Fillingim, Roger B.
疼痛过度警觉是疼痛的恐惧回避模型的一个重要方面，这可能有助于解释膝骨关节炎（OA）患者疼痛敏感性的个体差异。本研究的目的是检查疼痛过度警觉对症状性膝骨关节炎患者临床疼痛严重程度和实验疼痛敏感性的贡献。我们分析了168例症状性膝骨关节炎成人的横断面数据。定量感觉测试用于测量对热痛、压迫痛和冷痛的敏感性，以及热痛的时间总和，这是中枢敏感化的标志。疼痛过度警觉也是热痛时间总和的一个重要预测因子，疼痛过度警觉可能是膝关节OA患者疼痛报告和实验性疼痛敏感性的一个重要因素。
Pain hypervigilance is an important aspect of the fear-avoidance model of pain that may help explain individual differences in pain sensitivity among persons with knee osteoarthritis (OA).The purpose of this study was to examine the contribution of pain hypervigilance to clinical pain severity and experimental pain sensitivity in persons with symptomatic knee OA.We analyzed cross-sectional data from 168 adults with symptomatic knee OA. Quantitative sensory testing was used to measure sensitivity to heat pain, pressure pain, and cold pain, as well as temporal summation of heat pain, a marker of central sensitization.Pain hypervigilance was associated with greater clinical pain severity, as well as greater pressure pain. Pain hypervigilance was also a significant predictor of temporal summation of heat pain.Pain hypervigilance may be an important contributor to pain reports and experimental pain sensitivity among persons with knee OA.