Pumping fluids in microfluidic systems using the elastic deformation of poly(dimethylsiloxane).
Pumping fluids in microfluidic systems using the elastic deformation of poly(dimethylsiloxane).
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DOI：
10.1039/b714664g
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发表时间：
2007-11
期刊：
影响因子：
6.1
通讯作者：
D. Weibel;A. Siegel;A. Lee;Alexander H. George;G. Whitesides
中科院分区：
文献类型：
--
作者：
D. Weibel;A. Siegel;A. Lee;Alexander H. George;G. Whitesides
本文展示了一种用于存储和泵送流体的方法，该方法为微流体装置提供了有用的能力。它使用微流体螺旋阀来隔离聚二甲基硅氧烷（PDMS）微隔室中的流体，其中液体的压力存储在隔室的壁和天花板的弹性变形中。液体可以在这些结构中在压力下储存数月。当阀门打开时，壁和顶板将流体推出隔室进入微流体通道。该系统具有五个有用的特征：（i）其使用软光刻技术制成;（ii）其允许多种试剂预装载在装置中并在压力下储存，而无需任何额外的用户干预;（iii）其使得可以计量装置中的流体，并控制流体的流速;（iv）其防止用户暴露于潜在的有毒试剂;及（v）其为手动操作且不需要额外设备或资源。
This paper demonstrates a methodology for storing and pumping fluids that provide a useful capability for microfluidic devices. It uses microfluidic screw valves to isolate fluids in poly(dimethylsiloxane) (PDMS) microcompartments, in which the pressure of the liquid is stored in the elastic deformation of the walls and ceiling of the compartments. Fluids can be stored under pressure in these structures for months. When the valves are opened, the walls and ceiling push the fluid out of the compartments into microfluidic channels. The system has five useful characteristics: (i) it is made using soft lithographic techniques; (ii) it allows multiple reagents to be preloaded in devices and stored under pressure without any additional user intervention; (iii) it makes it possible to meter out fluids in devices, and to control rates of flow of fluids; (iv) it prevents the user from exposure to potentially toxic reagents; and (v) it is hand-operated and does not require additional equipment or resources.