Nodular gastritis in Japanese young adults: endoscopic and histological observations
Nodular gastritis in Japanese young adults: endoscopic and histological observations
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DOI：
10.1007/s00535-007-2073-5
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发表时间：
2007-08-01
影响因子：
6.3
通讯作者：
Haruma, Ken
中科院分区：
文献类型：
--
作者：
Shiotani, Akiko;Kamada, Tomoari;Haruma, Ken
背景。结节性胃炎（NG）的内镜检查结果的特点是存在幽门螺杆菌感染和滤泡性胃炎。最近，日本的观察结果表明可能与弥漫型胃癌有关。我们的目的是分析年轻人的窦结节和组织学评分。方法。患有上消化道 (GI) 症状或幽门螺杆菌抗体阳性的受试者（55 名男性和 45 名女性；年龄范围 18-25 岁）接受了内窥镜检查。从主体的较大曲率和较小曲率（曲线）以及胃窦的较大曲率和较小曲率（曲线）中各获得一个样本。使用 0.2% 靛蓝胭脂红评估内镜外观，并通过更新的悉尼系统评估组织病理学分级。结果。 17 名幽门螺杆菌阴性受试者中没有发现胃窦结节，而 83 名幽门螺杆菌阳性受试者中的 55 名 (66.3%) 没有发现胃窦结节。根据胃窦内结节状或颗粒状隆起病变的分布，NG分为弥漫性（n = 27）或非弥漫性（n = 28）类型。弥漫型 NG 主要影响女性（比值比，3.9；95% 置信区间，1.5-10）。非弥漫性组中胃窦小曲线的萎缩分数显着高于弥漫性组。然而，三组之间的活动、炎症和幽门螺杆菌密度评分没有显着差异。结论。弥漫型 NG 取决于性别，窦结节似乎从弥漫型转变为非弥漫型，与萎缩有关。
Background. Endoscopic findings of nodular gastritis (NG) are characterized by the presence of Helicobacter pylori infection and follicular gastritis. A possible association with diffuse-type gastric cancer has recently been suggested from observations in Japanese. Our aim was to analyze antral nodularity and histological scores in young adults. Methods. Subjects (55 men and 45 women; age range, 18-25 years) with upper gastrointestinal (GI) symptoms or positive H. pylori antibodies underwent endoscopy. One specimen each was obtained from the greater and lesser curvatures (curves) of the corpus and from those of the antrum. Endoscopic appearance was assessed using 0.2% indigo carmine, and histopathological grading was evaluated by the updated Sydney System. Results. Antral nodularity was identified in none of 17 H. pylori-negative subjects and in 55 of 83 (66.3%) H. pylori-positive subjects. By the distribution of nodular or granular elevated lesions in the antrum, NG was divided into diffuse (n = 27) or nondiffuse (n = 28) types. The diffuse-type NG predominantly affected women (odds ratio, 3.9; 95% confidence interval, 1.5-10). The atrophy scores in the lesser curve of the antrum were significantly higher in the nondiffuse than in the diffuse group. However, the scores for activity, inflammation, and H. pylori density were not significantly different among the three groups. Conclusions. Diffuse-type NG depended on sex, and antral nodularity seemed to change from the diffuse to the nondiffuse type in association with atrophy.