Learning and memory formation in the honeybee (Apis mellifera) and its dependency on the cAMP-protein kinase A pathway
Learning and memory formation in the honeybee (Apis mellifera) and its dependency on the cAMP-protein kinase A pathway
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DOI：
10.1163/157075606777304249
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发表时间：
2006-06-01
期刊：
影响因子：
1.2
通讯作者：
Eisenhardt, Dorothea
中科院分区：
文献类型：
--
作者：
Eisenhardt, Dorothea
蜜蜂（Apis mellifera）是研究学习记忆、形成及其机制的模式生物。蜜蜂有丰富的行为，可以在野外和实验室中进行研究。在后一种情况下，嗅觉条件反射的长鼻延伸反应（PER）已被深入研究的神经元和分子机制的收购和记忆的形成。关于非条件刺激和条件刺激的神经通路，我们已经知道了很多，导致记忆形成的分子机制也已经确定。尤其是。已经分析了cAMP-蛋白激酶A途径在记忆形成中的作用。本文概述了记忆形成的分子基础. cAMP依赖性信号级联在记忆形成中的作用进行了总结，并讨论了非联想和联想学习激活这一途径。
The honeybee (Apis mellifera) is a model organism for the study of learning and memory, formation and its underlying mechanisms. Honeybees have a rich behaviour that can be studied in the field as well as in the laboratory. In the latter case, olfactory conditioning of the proboscis extension response (PER) has been intensively studied with respect to the neuronal and molecular mechanisms underlying acquisition and memory formation. Quite a lot is known about the neuronal pathways of both the unconditioned and the conditioned stimulus, and molecular mechanisms that lead to memory formation have been identified. In particular. the role of the cAMP-protein kinase A pathway in memory formation has been analysed. Present knowledge about the molecular basis of memory formation is Outlined here. The role of the cAMP-dependent signalling cascade in memory formation is summarised and the activation of this pathway by non-associative and associative learning is discussed.