Effects of glutathione S-transferase M1 and T1 deletions on epilepsy risk among a Tunisian population
Effects of glutathione S-transferase M1 and T1 deletions on epilepsy risk among a Tunisian population
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DOI：
10.1016/j.eplepsyres.2014.05.009
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发表时间：
2014-09-01
影响因子：
2.2
通讯作者：
Saguem, Saad
中科院分区：
文献类型：
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作者：
Chbili, Chahra;B'chir, Fatma;Saguem, Saad
谷胱甘肽-S-转移酶参与多种内源性和外源性物质的解毒。在本研究中，我们评估了两个谷胱甘肽-S-转移酶多态性（GSTM 1和GSTT 1）对突尼斯人群癫痫风险易感性的影响，这些多态性在229名健康受试者和98例癫痫患者中进行了分析，使用聚合酶链反应（PCR）。结果表明，GSTM 1缺失基因型的个体患癫痫的危险性增加[OR = 3.80，95%可信区间（CI）]，GSTM 1缺失基因型的个体患癫痫的危险性增加[OR = 3.80，95%可信区间（CI）]。（2.15-4.78）]，而GSTT 1缺失基因型个体与癫痫风险之间未观察到显著影响[OR = 1.15，95%CI（0.62-2.12）]。这些基因分型结果显示GSTM 1活性的缺失可能是癫痫疾病发生的促发因素。(C)2014爱思唯尔有限公司版权所有。
Glutathione-S-transferases enzymes are involved in the detoxification of several endogenous and exogenous substances. In this present study, we evaluated the effects of two glutathione-S-transferase polymorphisms, (GSTM1 and GSTT1) on epilepsy risk susceptibility in a Tunisian population.These polymorphisms were analyzed in 229 healthy subjects and 98 patients with epilepsy, using a polymerase chain reaction (PCR). Odds ratio (ORs) was used for analyzing results.The study results demonstrated that individuals with the GSTM1 null genotype-were at an increased risk of developing epilepsy [OR = 3.80, 95% confidence interval (CI) (2.15-4.78)], whereas no significant effects were observed between individuals with GSTT1 null genotype and epilepsy risk [OR = 1.15, 95% CI (0.62-2.12)].These genotyping finding revealed that the absence of GSTM1 activity could be contributor factor for the development of epilepsy disease. (C) 2014 Elsevier B.V. All rights reserved.