Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses
Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses
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DOI：
10.1046/j.1365-2567.2002.01396.x
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发表时间：
2002-05-01
期刊：
影响因子：
6.4
通讯作者：
Diamond, DJ
中科院分区：
文献类型：
--
作者：
BenMohamed, L;Krishnan, R;Diamond, DJ
肠外注射含有来自人巨细胞病毒（HCMV）免疫显性基质蛋白pp 65的人白细胞抗原（HLA）-A*0201限制性细胞毒性T淋巴细胞（CTL）表位的脂肽有效地诱导HLA-A*0201转基因小鼠的系统性CTL应答。在这项研究中，我们证明了鼻内（i.n.）施用这种与通用T辅助（Th）表位（PADRE）共价连接的脂肽也诱导有效的全身性CTL应答。当使用非脂化肽类似物时，免疫应答显著降低（P
Parenteral injection of a lipopeptide containing a human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T-lymphocyte (CTL) epitope from the human cytomegalovirus (HCMV) immunodominant matrix protein pp65 efficiently induces systemic CTL responses in HLA-A*0201 transgenic mice. In this study, we demonstrate that intranasal (i.n.) administration of this lipopeptide, covalently linked to a universal T helper (Th) epitope (PADRE), also induces potent systemic CTL responses. Immune responses were substantially reduced when the unlipidated peptide analogue was used (P