Prostate cancer risk in California farm workers
Prostate cancer risk in California farm workers
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DOI：
10.1097/01.jom.0000058339.05741.0c
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发表时间：
2003-03-01
影响因子：
3.2
通讯作者：
Yang, R
中科院分区：
文献类型：
--
作者：
Mills, PK;Yang, R
之前的研究已经评估了农场劳动人口中的前列腺癌，尽管不是全部，但大多数都发现农民和农场工人患前列腺癌的风险增加。具体的职业风险因素尚未确定。一项关于前列腺癌的嵌套病例对照研究是在加利福尼亚州以西语裔为主的工会--美国农场工人联合会的一个大队列中进行的。通过在1988年至1999年的工会成员名册和加州癌症登记处之间进行电子记录联系，在工会内发现了新诊断的前列腺癌病例。年龄匹配的对照组是从其余的无癌症队列中随机挑选出来的。通过检查农场工人种植的作物和商品的类型以及第一次工会活动的日期和加入工会的持续时间来检查前列腺癌的风险。此外，根据加州农药监管部门记录的几种杀虫剂的使用情况，评估了前列腺癌的风险。1988至1999年间，对222例新诊断的前列腺癌病例进行了分析，并选择了1110名年龄匹配的对照组。前列腺癌的风险与任何作物/商品的就业模式无关。加入工会的时间越长，患前列腺癌的风险越低。尽管在雇用农场工人的年份和县使用的农药总量与风险无关，但使用特定的化学品，包括西马津、林丹和七氯，风险会增加，敌敌畏和甲基溴的风险也会增加。我们的结论是，与接触水平较低的工人相比，接触有机氯农药(林丹和七氯)、有机磷农药(敌敌畏)、熏蒸剂(甲基溴)或三嗪除草剂(西马津)水平相对较高的西班牙裔农场工人患前列腺癌的风险较高。
Previous studies have evaluated prostate cancer in farm-working populations and most, although not all, have found an elevated risk of this cancer in farmers and farm workers. Specific occupational risk factors have not been identified. A nested case-control study of prostate cancer was conducted within a large cohort of a predominantly Hispanic labor union in California, the United Farm Workers of America. By conducting an electronic record linkage between a roster of the union members and the California Cancer Registry for the years 1988 through 1999, newly diagnosed cases of prostate cancer were identified within the union. Age-matched controls were randomly selected from the remainder of the cancer-free cohort. Risk for prostate cancer was examined by examining the type of crops and commodities cultivated by the farm workers as well as by the date of first union activity and duration of union affiliation. In addition, the risk of prostate cancer was evaluated in association with use of several pesticides recorded by the California Department Of Pesticide Regulation. Between 1988 and 1999, 222 newly diagnosed prostate cancer cases were identified for analysis and 1110 age-matched controls were selected. The risk of prostate cancer was not associated with patterns of employment in any crop/commodity. Increasing duration of union affiliation was associated with decreasing prostate cancer risk. Although risk was not associated with total pounds of pesticides applied in the years and counties where farm workers were employed, risk was increased with specific chemicals, including simazine, lindane, and heptachlor, and suggestive increases were observed with dichlorvos and methyl bromide. We concluded that Hispanic farm workers with relatively high levels of exposure to organochlorine pesticides (lindane and heptachlor), organophosphate pesticides (dichlorvos), fumigants (methyl bromide), or triazine herbicides (simazine) experienced elevated risk of prostate cancer compared to workers with lower levels of exposure.