Facile synthesis of ZnO nanoparticles by Actinidia deliciosa fruit peel extract: Bactericidal, anticancer and detoxification properties
Facile synthesis of ZnO nanoparticles by Actinidia deliciosa fruit peel extract: Bactericidal, anticancer and detoxification properties
复制标题
利用美味猕猴桃果皮提取物轻松合成氧化锌纳米粒子：杀菌、抗癌和解毒特性
DOI：
10.1016/j.envres.2021.111433
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发表时间：
2021-06-15
影响因子：
8.3
通讯作者：
Wu, Yunbo
中科院分区：
文献类型：
--
作者：
Li, Jie;Li, Yi;Wu, Yunbo
纳米氧化锌具有良好的生物相容性，在催化剂、杀菌剂、癌症治疗、传感器等方面有着广泛的应用前景，因此通过环境友好的方法合成纳米氧化锌受到了广泛的关注。虽然制备纳米氧化锌的化学方法多种多样，但利用植物材料合成纳米氧化锌是一种很好的替代方法，也是一种绿色方法。以美味猕猴桃（Actinidia deliciosa，Kiwi）果皮提取物为原料，采用低成本的绿色合成方法制备了纳米氧化锌，并对其优良的生物学和催化性能进行了研究。采用紫外可见光谱、X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）和能量色散X射线能谱（EDAX）对合成的纳米粒子进行了表征。采用金黄色葡萄球菌（S.金黄色葡萄球菌），同时通过SEM图像研究细胞死亡机制。在抑制结肠癌细胞（HCT 116）中也观察到ZnO纳米颗粒的上级抗癌活性。此外，ZnO纳米粒子表现出高效的光催化活性对溴苯酚的降解，约96.3%，在120分钟内。此外，中间产物的植物毒性进行了分析，使用绿豆（V.辐射）作为模式植物。在p-BP纯品中，发芽指数（GI）由8.0%上升到82.3%，表明p-BP在120 min降解后已达到脱毒。因此，本研究表明，通过简单、快速、廉价、环保和高效的绿色方法制备的纳米ZnO为生物医学和废水处理技术提供了新的选择。
Synthesis of nanoparticles by eco-friendly method pulled an extensive concern worldwide due its biocompatibility and wide range of applications as catalysts, microbicidal agents, cancer treatment, sensors etc. Though different chemical methods available for preparation of ZnO nanoparticles, synthesis by utilizing plant material is an excellent substitute and green method as well. The present study describes preparation of ZnO nanoparticles by low-cost green synthetic way using Actinidia deliciosa (kiwi) fruit peel extract and its excellent biological and catalytic properties. The synthesized nanoparticles were well characterized by UV visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM) and Energy-dispersive X-ray spectroscopy (EDAX). The bactericidal activity of the ZnO nanoparticles was determined by using Staphylococcus aureus (S. aureus), while mechanism of cell death was studied by SEM images. Superior anticancer activity was also observed in inhibiting the colon cancer cells (HCT116) by the ZnO nanoparticles. In addition, ZnO nanoparticles showed efficient photocatalytic activity towards degradation of p-bromophenol, about 96.3% within 120 min. Furthermore, phytotoxicity of the intermediate products was analyzed using Vigna radiata (V. radiata) as a model plant. About 8.0% of germination index (GI) was observed in pure p-BP while it increased to 82.3%, and exhibited that the detoxification of p-BP was attained after 120 min of degradation. Thus, the present study demonstrates ZnO nanoparticles prepared from simple, rapid, inexpensive, eco-friendly and efficient green method gives alternative root for biomedicine and wastewater treatment technologies.