Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring
Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring
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DOI：
10.1111/j.1399-3038.2011.01202.x
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发表时间：
2011-12-01
影响因子：
4.4
通讯作者：
Virtanen, Suvi M.
中科院分区：
文献类型：
--
作者：
Lumia, Mirka;Luukkainen, Paivi;Virtanen, Suvi M.
背景：脂肪酸（FA）调节免疫系统，并且已经提出它们影响IgE介导的过敏性疾病的发病率。我们探讨了母亲的饮食FA组成在怀孕期间与哮喘的风险在office.Methods：我们分析了芬兰1型糖尿病预测和预防（DIPP）营养研究的数据。母亲在怀孕期间（第8个月）的饮食摄入量进行了评估，验证了181项食物频率问卷。在5岁时用国际儿童哮喘和过敏研究（ISAAC）的问卷调查评估哮喘的发生。采用考克斯比例风险回归进行统计分析。结果：母亲摄入α-亚麻酸水平低（十八：3 n-3）[最低季度与中半年HR 1.67（95% CI 1.122.48）]和总n-3-多不饱和脂肪酸（多不饱和脂肪酸）[HR 1.66（95%CI 1.112.48）]与后代哮喘风险增加相关，而花生四烯酸摄入量低（20：4 n-6）[HR 0.52（95% CI 0.320.84）]和总饱和脂肪酸摄入量高[最高四分之一vs.中半部分HR 0.55（95% CI 0.340.90）]和棕榈酸（16：0）[HR 0.51（95% CI 0.310.83）]与哮喘风险降低相关。n-6与n-3-PUFA和18：2n-6与18：3 n-3的比例，以及母亲摄入油，鱼和鱼产品，与哮喘的风险无关。发现的协会是独立的围产期和临床confronters.Conclusion：母亲在怀孕期间摄入FA与儿童哮喘。母体α-亚麻酸、总n-3 PUFA和棕榈酸摄入量可能减少，而花生四烯酸摄入量可能增加后代患哮喘的风险。
Background: Fatty acids (FA) modulate the immune system, and it has been proposed that they affect the incidence of IgE-mediated allergic diseases. We explored the association of maternal dietary FA composition during pregnancy with the risk of asthma in the offspring.Methods: We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. Maternal dietary intake during pregnancy (8th month) was assessed by a validated 181-item food frequency questionnaire. The occurrence of asthma was assessed at the age of 5 yr with a questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC). Cox proportional hazards regression was used for the statistical analyses.Results: Low maternal intakes of a-linolenic acid (18:3n-3) [lowest quarter vs. mid-half HR 1.67 (95% CI 1.122.48)] and total n-3-polyunsaturated fatty acids (PUFA) [HR 1.66 (95% CI 1.112.48)] during pregnancy were associated with an increased risk of asthma in the offspring, while a low intake of arachidonic acid (20:4n-6) [HR 0.52 (95% CI 0.320.84)] and high intake of total saturated fatty acids [highest quarter vs. mid-half HR 0.55 (95% CI 0.340.90)] and palmitic acid (16:0) [HR 0.51 (95% CI 0.310.83)] were associated with a decreased risk of asthma. The ratios of n-6 to n-3-PUFA and 18:2n-6 to 18:3n-3, and the maternal intake of oils, fish and fish products, showed no association with the risk of asthma. The associations found were independent of several perinatal and clinical confounders.Conclusion: Maternal intake of FA during pregnancy was associated with childhood asthma. Maternal a-linolenic acid, total n-3 PUFA and palmitic acid intake may decrease, while arachidonic acid intake may increase the risk of asthma in the offspring.