Atrial natriuretic peptide infusion improves ischemic renal failure after suprarenal abdominal aortic cross-clamping in dogs
Atrial natriuretic peptide infusion improves ischemic renal failure after suprarenal abdominal aortic cross-clamping in dogs
复制标题
心房利钠肽输注可改善犬肾上腹主动脉阻断后缺血性肾功能衰竭
DOI：
10.1097/01.ccm.0000080487.20304.2e
复制
发表时间：
2003
影响因子：
8.8
通讯作者：
T. Imai
中科院分区：
文献类型：
--
作者：
C. Mitaka;Y. Hirata;K. Habuka;Y. Narumi;K. Yokoyama;K. Makita;T. Imai
主动脉瘤修补术中肾上腹主动脉交叉夹闭导致术后肾功能不全。心房利钠肽（ANP）是一种由心房合成的激素，可诱导利尿钠排泄并增加肾小球滤过率。因此，我们验证了预防性心钠素输注可以限制主动脉阻断后急性肾功能衰竭的发展的假设。设计前瞻性、比较性、实验性研究。在一所大学医院的实验室。12只雄性比格犬（10-13 kg），在戊巴比妥麻醉下进行机械通气。干预将导管插入股静脉，并在整个研究期间给予乳酸林格氏溶液（10 mL/kg/hr）。研究了两组动物：对照组（n = 6），在肾上腹主动脉交叉夹闭1.5小时之前和之后接受盐水载体;和ANP组（n = 6），从肾上腹主动脉交叉夹闭之前10分钟开始直到手术结束接受ANP（lg/kg/min）5小时。测量和主要结果在主动脉阻断后1，2，3，4和5小时测量全身和肾脏血流动力学，血气和肾功能的变化。主动脉阻断后，尿量、肾血流量和肌酐清除率显著降低（p <0.01），血清肌酐浓度显著升高（p <0.01），但这些作用受到持续ANP输注的限制。结论静脉输注ANP可保护肾上腹主动脉阻断后的肾功能。这些结果证明了在主动脉瘤修复期间在人体中进行ANP输注的试验。
ObjectiveThe suprarenal abdominal aortic cross-clamping during aortic aneurysm repair causes renal dysfunction after surgery. Atrial natriuretic peptide (ANP), a hormone synthesized by the cardiac atria, induces diuresis-natriuresis and increases glomerular filtration rate. Therefore, we tested the hypothesis that prophylactic ANP infusion could limit the development of acute renal failure after aortic cross-clamping. DesignProspective, comparative, experimental study. SettingLaboratory at a university hospital. SubjectsTwelve male beagle dogs (10–13 kg) with mechanical ventilation under pentobarbital anesthesia. InterventionsA catheter was inserted into the femoral vein, and lactated Ringer solution (10 mL/kg/hr) was administered throughout the study period. Two groups of animals were studied: the control group (n = 6), which received saline vehicle before and after suprarenal abdominal aortic cross-clamping for 1.5 hrs; and the ANP group (n = 6), which received ANP (1 &mgr;g/kg/min) for 5 hrs, starting from 10 mins before suprarenal abdominal aortic cross-clamping until the end of procedure. Measurements and Main ResultsChanges in systemic and renal hemodynamics, blood gases, and renal function were measured at baseline and 1, 2, 3, 4, and 5 hrs after aortic cross-clamping. After aortic cross-clamping, urine volume, renal blood flow, and creatinine clearance significantly (p < .01) decreased, and serum creatinine concentrations significantly (p < .01) increased, but these effects were limited by continuous ANP infusion. ConclusionsThe present study shows that ANP infusion preserved renal function after suprarenal abdominal aortic cross-clamping in dogs. These results justify a trial of ANP infusion in humans during aortic aneurysm repair.
影响因子：
19.6
作者：
Joseph Winaver;John C. Burnett;G. M. Tyce;T. Dousa
通讯作者：
Joseph Winaver;John C. Burnett;G. M. Tyce;T. Dousa
atriopeptin III 对离体大鼠传入和传出小动脉的影响。
DOI：
10.1152/ajprenal.1991.261.6.f1102
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Lanese,DM;Yuan,BH;Falk,SA;Conger,JD
通讯作者：
Conger,JD