An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia
An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia
复制标题
DOI：
10.5551/jat.19976
复制
发表时间：
2014-01-01
影响因子：
4.4
通讯作者：
Shimatsu, Akira
中科院分区：
文献类型：
--
作者：
Ito, Ryo;Satoh-Asahara, Noriko;Shimatsu, Akira
目的：流行病学研究表明n-6/n-3多不饱和脂肪酸的比例与心血管疾病有关。在此，我们研究了高纯度二十碳五烯酸(EPA)对动脉僵硬的有利作用是否与肥胖日本血脂异常患者多不饱和脂肪酸(如EPA、二十二碳六烯酸(DHA)和双高-伽马亚麻酸(DGLA)相对于花生四烯酸(AA)的比率的变化有关。方法：比较94例有血脂异常的肥胖患者和31例无血脂异常的肥胖患者的EPA/AA、DHA/AA和DGLA/AA的比率。结果：肥胖合并血脂异常组DHA/AA和DGLA/AA比值均显著高于非肥胖组(P<；0.05)，而EPA/AA比值在肥胖合并血脂异常组与非肥胖组间差异无统计学意义。治疗3个月后，与对照组相比，EPA显著降低了血红蛋白A1c、总胆固醇、甘油三酯、C反应蛋白、心踝血管指数(CAVI)和DGLA/AA比值。另一方面，EPA可显著提高脂联素水平和EPA/AA比值(P
Aim: Previous epidemiological studies demonstrated that the ratio of n-6 to n-3 polyunsaturated fatty acids is associated with cardiovascular diseases. We herein investigated whether the beneficial effect of highly purified eicosapentaenoic acid (EPA) on arterial stiffness is associated with changes in the ratio of polyunsaturated fatty acids, such as EPA, docosahexaenoic acid (DHA) and dihomo-gamma-linolenic acid (DGLA), relative to arachidonic acid (AA), in obese Japanese patients with dyslipidemia.Methods: The EPA/AA, DHA/AA and DGLA/AA ratios were compared between obese patients with (n=94) and without (n=31) dyslipidemia. Among the former group, 88 patients received either highly purified EPA treatment (1.8 g daily, n=45) or treatment without EPA (control, n=43).Results: At baseline, the ratios of DHA/AA and DGLA/AA were significantly (P < 0.05) higher in obese patients with dyslipidemia than in those without, while the EPA/AA ratio was similar between patients with and without dyslipidemia. EPA significantly reduced the hemoglobin A1c, total cholesterol, triglycerides, CRP, cardio-ankle vascular index (CAVI) (an index of arterial stiffness) and the DGLA/AA ratio relative to the control at three months after the treatment. On the other hand, EPA significantly increased the adiponectin level and EPA/AA ratio (P