Utility of USPIO-enhanced MR imaging to identify inflammation and the fibrous cap: A comparison of symptomatic and asymptomatic individuals
Utility of USPIO-enhanced MR imaging to identify inflammation and the fibrous cap: A comparison of symptomatic and asymptomatic individuals
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DOI：
10.1016/j.ejrad.2008.01.047
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发表时间：
2009-06-01
影响因子：
3.3
通讯作者：
Gillard, J. H.
中科院分区：
文献类型：
--
作者：
Howarth, S. P. S.;Tang, T. Y.;Gillard, J. H.
背景与目的：炎症是易损斑块形成的危险因素.这可以通过使用造影剂Sinerem（TM）（一种超小超顺磁性氧化铁（USPIO））的高分辨率磁共振（MR）成像在体内检测到。本研究的目的是探讨在有症状和无症状颈动脉斑块之间，使用USPIO颗粒的MR定义的炎症程度是否存在差异。我们进一步报告其T，增强纤维帽，这可能会让双重对比分辨率颈动脉粥样硬化的效果。方法：20例颈动脉狭窄（10症状和10无症状）进行了多序列MR成像前和36小时后USPIO输液。将图像手动分割成象限，并在USPIO施用后计算每个象限中的信号变化。结果：有症状的患者比无症状的患者有更多的信号下降的象限（75%比32%，p
Background and purpose: Inflammation is a risk factor the vulnerable atheromatous plaque. This can be detected in vivo on high-resolution magnetic resonance (MR) imaging using a contrast agent, Sinerem (TM), an ultra-small super-paramagnetic iron oxide (USPIO). The aim of this study was to explore whether there is a difference in the degree of MR defined inflammation using USPIO particles, between symptomatic and asymptomatic carotid plaques. We report further on its T, effect of enhancing the fibrous cap, which may allow dual contrast resolution of carotid atheroma.Methods: Twenty patients with carotid stenosis (10 symptomatic and 10 asymptomatic) underwent multi-sequence MR imaging before and 36 h post-USPIO infusion. Images were manually segmented into quadrants and signal change in each quadrant was calculated following USPIO administration. Mean signal change across all quadrants were compared between the two groups.Results: Symptomatic patients had significantly more quadrants with a signal drop than asymptomatic individuals (75% vs. 32%, p