Allelic loss at 1 p is associated with tumor progression of meningiomas
Allelic loss at 1 p is associated with tumor progression of meningiomas
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1 p 等位基因丢失与脑膜瘤的肿瘤进展相关
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
Jose L. Sarasay
中科院分区：
文献类型：
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作者：
M. Bello;A. Pestaña;J. Rey;J. D. de Campos;M. Kusak;J. Vaquero;Jose L. Sarasay
在脑膜瘤的细胞遗传学分析中，仅次于22号染色体异常，I号染色体短臂缺失被描述为最常见的改变。为了确定这些缺失的发生率，我们分析了一系列50例脑膜瘤四个染色体I基因座的等位基因丢失。在所研究的标记中，有13个样本表现出杂合性缺失；其中一个样本的结果与整个I染色体的丢失是一致的，而在另外12个样本中观察到短臂的缺失。此前有11例脑膜瘤在22号染色体上有等位基因丢失，其中12例的特征是肿瘤侵袭性增加。这些发现表明，1p的缺失(或位于那里的一个基因的改变)可能代表脑膜瘤的继发性但非随机的改变，可能有助于脑膜瘤的进展。基因铬癌9：296-298(1994)。©1994 Wiley-Liss。Inc.
Next to chromosome 22 anomalies, deletions of the short arm of chromosome I have previously been described as the most frequent alteration detected by cytogenetic analysis of meningiomas. To determine the incidence of these deletions, we have analyzed a series of 50 meningiomas for the loss of alleles at four chromosome I loci. Thirteen samples displayed LOH for the markers studied; in one instance, the results were compatible with loss of the entire chromosome I, whereas in the other 12 samples deletions of the short arm were observed. Eleven of the meningiomas had previously been shown to have loss of alleles on chromosome 22, and 12 of them were characterized by increased tumor aggressiveness. These findings suggest that deletion of 1p (or the alteration of a locus located there) might represent a secondary, but nonrandom alteration in meningiomas, perhaps contributing to meningioma tumor progression. Genes Chrom Cancer 9:296‐298 (1994). © 1994 Wiley‐Liss. Inc.
人类脑膜瘤的分子遗传学方法：22 号染色体上的基因丢失。
DOI：
10.1073/pnas.84.15.5419
发表时间：
1987
影响因子：
11.1
作者：
Seizinger,BR;delaMonte,S;Atkins,L;Gusella,JF;Martuza,RL
通讯作者：
Martuza,RL