Impaired flexibility in decision making in rats after administration of the pharmacological stressor yohimbine.
Impaired flexibility in decision making in rats after administration of the pharmacological stressor yohimbine.
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DOI：
10.1007/s00213-014-3529-y
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发表时间：
2014-10
影响因子：
3.4
通讯作者：
Taha, Sharif A.
中科院分区：
文献类型：
--
作者：
Schwager, Andrea L.;Haack, Andrew K.;Taha, Sharif A.
压力导致的决策中断被假设为导致药物寻求行为和成瘾。去甲肾上腺素能信号在介导应激反应中起着核心作用。然而，急性应激对决策的影响，以及去甲肾上腺素能信号在调节这些影响中的作用，还没有得到很好的表征。为了描述急性药物应激引起的决策变化，在延迟折扣任务中检查了育亨宾（α2-肾上腺素能拮抗剂）的作用。通过检查普萘洛尔（一种β受体拮抗剂）、哌唑嗪（一种α 1受体拮抗剂）和胍法辛（一种α2受体激动剂）的作用，进一步表征了去甲肾上腺素能对决策的贡献。Sprague-Dawley大鼠在执行延迟折扣任务之前给予药物，其中在每个会话内大奖励之前的延迟增加（递增延迟）。为了将药物引起的延迟敏感性变化与行为敏感性分离，随后在折扣任务的修改版本中测试了药物效应，其中在每个会话中大奖励之前的延迟减少（递减延迟）。育亨宾增加选择的大奖励时，测试上升延迟，但减少选择相同的大奖励时，测试下降延迟，这表明药物的影响可能是由于坚持选择的杠杆首选在会议开始。普萘洛尔增加了选择的大奖励时，测试与上升延迟。哌唑嗪和胍法辛对奖赏选择没有影响。育亨宾给药的压力样效应可能会通过引起僵硬、固执的行为而损害决策能力。
Stress-induced disruption of decision making has been hypothesized to contribute to drug-seeking behaviors and addiction. Noradrenergic signaling plays a central role in mediating stress responses. However, the effects of acute stress on decision making, and the role of noradrenergic signaling in regulating these effects, have not been well characterized. To characterize changes in decision making caused by acute pharmacological stress, the effects of yohimbine (an α2-adrenergic antagonist) were examined in a delay discounting task. Noradrenergic contributions to decision making were further characterized by examining the effects of propranolol (a β antagonist), prazosin (an αl antagonist), and guanfacine (an α2 agonist). Sprague-Dawley rats were administered drugs prior to performance on a delay discounting task, in which the delay preceding the large reward increased within each session (ascending delays). To dissociate drug-induced changes in delay sensitivity from behavioral inflexibility, drug effects were subsequently tested in a modified version of the discounting task, in which the delay preceding the large reward decreased within each session (descending delays). Yohimbine increased choice of the large reward when tested with ascending delays but decreased choice of the same large reward when tested with descending delays, suggesting that drug effects could be attributed to perseverative choice of the lever preferred at the beginning of the session. Propranolol increased choice of the large reward when tested with ascending delays. Prazosin and guanfacine had no effect on reward choice. The stress-like effects of yohimbine administration may impair decision making by causing inflexible, perseverative behavior.
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影响因子：
3.4
作者：
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通讯作者：
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作者：
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