Association Between Circulating Monocytes and Coronary Plaque Progression in Patients With Acute Myocardial Infarction
Association Between Circulating Monocytes and Coronary Plaque Progression in Patients With Acute Myocardial Infarction
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DOI：
10.1253/circj.cj-09-0779
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发表时间：
2010-07-01
影响因子：
3.3
通讯作者：
Kimura, Kazuo
中科院分区：
文献类型：
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作者：
Nozawa, Naoki;Hibi, Kiyoshi;Kimura, Kazuo
背景：单核细胞和巨噬细胞在动脉粥样硬化的发展过程中发挥着重要作用。本研究探讨循环单核细胞计数能否预测急性心肌梗死(AMI)非肇事中间病变的冠状动脉斑块进展。方法与结果：分析90例急性心肌梗死患者急性期及7个月随访的非肇事中间斑块的血管内超声表现。急性心肌梗死后单核细胞峰值数越高，斑块体积变化越大(r=0.32，P=0.002)。多变量分析显示，单核细胞数峰值为800/mm(3)是斑块进展的独立预测因素(优势比为5.02，P=0.005)。在7个月的随访期中，高单核细胞数(t；=800/mm(3))显著高于低单核细胞数(368+/-109vs263+/-/mm(3)，P
Background: Monocytes and macrophages have been shown to play major roles in the progression of atherosclerosis. This study examined whether the circulating monocyte count can be used to predict coronary plaque progression of non-culprit intermediate lesions in acute myocardial infarction (AMI).Methods and Results: Intravascular ultrasound findings of non-culprit intermediate plaque in 90 patients were analyzed in the acute phase and at a 7-month follow up. A higher peak monocyte count after AMI was associated with a greater plaque volume change (r=0.32, P=0.002). Multivariate analysis showed that a peak monocyte count of >= 800/mm(3) was an independent predictor of plaque progression (odds ratio 5.02, P=0.005). High monocyte (>= 800/mm(3)) at baseline had a higher monocyte count at 7-month follow up than did those with a lower count (368+/-109 vs 263+/-64/mm(3), P