Precision of measurements of right and left ventricular volume by cine computed tomography.
Precision of measurements of right and left ventricular volume by cine computed tomography.
复制标题
通过电影计算机断层扫描测量右心室和左心室容积的精度。
DOI：
10.1161/01.cir.74.4.890
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发表时间：
1986
期刊：
影响因子：
37.8
通讯作者：
Marcus,ML
中科院分区：
文献类型：
--
作者：
Reiter,SJ;Rumberger,JA;Feiring,AJ;Stanford,W;Marcus,ML
传统成像技术对左心室和右心室每搏输出量的精确测定受到限制。我们确定是否可以通过电影计算机断层扫描 (CT) 精确测量右心室和左心室每搏输出量。电影 CT 能够以 8 毫米切片厚度同时对左右心室进行成像，最大扫描速率为 17 帧/秒（50 毫秒采集间隔）。在八只狗中，真实的右心室和左心室每搏输出量是通过将热稀释心输出量除以心率和/或使用长期植入的主动脉电磁流量探针来确定的。暂停呼吸至少 5 秒后，在中心静脉注射非离子造影剂期间获取电影 CT 图像。通过给予多巴酚丁胺、戊巴比妥钠或硝普钠或通过冠状动脉闭塞，在每只狗中诱导每搏输出量的多次扰动。右心室和左心室每搏输出量通过辛普森重建从心尖到基部的舒张末期和收缩末期短轴断层图获得。电影 CT 左心室每搏输出量（范围 11 至 45 ml）与真实左心室每搏输出量高度相关（r = .99，斜率 = 1.01，y 截距 = -0.2 ml，SEE = 1.5 ml，n = 25）。电影 CT 右心室每搏输出量（范围 11 至 34 ml）也与真实右心室每搏输出量高度相关（r = .98，斜率 = 0.9，y 截距 = 2.2 ml，SEE = 1.7 ml，n = 15）。在 12 项研究中，通过电影 CT 测量几乎同时出现的右心室和左心室每搏输出量之间的平均差异为 1.1 ml（范围 0.1 至 3.2 ml）。根据电影 CT 数据计算右心室和左心室每搏输出量具有高度可重复性。右心室每搏输出量（r = 1.0，斜率 = 0.99，y 截距 = 0.19 ml）和左心室每搏输出量（r = 1.0，斜率 = 1.02，y 截距 = -0.21 ml）测量值的观察者内变异性极小。右心室每搏输出量（r = .98，斜率 = 0.90，y 截距 = 1.66 ml）和左心室每搏输出量（r = .99，斜率 = 0.97，y 截距 = -0.02 ml）测量值的观察者间变异性同样很小。因此，可以通过电影 CT 获得右心室和左心室每搏输出量的精确且高度可重复的测量。
Precise determination of left and right ventricular stroke volumes is limited with conventional imaging techniques. We determined whether right and left ventricular stroke volumes could be precisely measured with cine computed tomography (CT). Cine CT enables simultaneous imaging of the right and left ventricles at an 8 mm slice thickness with a maximal scanning rate of 17 frames/sec (50 msec acquisition intervals). In eight dogs, true right ventricular and left ventricular stroke volumes were determined by dividing thermodilution cardiac output by heart rate and/or with the use of an aortic electromagnetic flow probe implanted over a long term. After at least 5 sec of suspended respiration, cine CT images were acquired during central venous injection of a nonionic contrast agent. Multiple perturbations in stroke volume were induced in each dog by the administration of dobutamine, sodium pentobarbital, or sodium nitroprusside or by coronary artery occlusion. Right and left ventricular stroke volumes were obtained by Simpson's reconstruction of end-diastolic and end-systolic short-axis tomograms from apex to base. The cine CT left ventricular stroke volume (range 11 to 45 ml) correlated highly with the true left ventricular stroke volume (r = .99, slope = 1.01, y intercept = -0.2 ml, SEE = 1.5 ml, n = 25). The cine CT right ventricular stroke volume (range 11 to 34 ml) also correlated highly with the true right ventricular stroke volume (r = .98, slope = 0.9, y intercept = 2.2 ml, SEE = 1.7 ml, n = 15). In 12 studies, the mean difference between nearly simultaneous right and left ventricular stroke volumes by cine CT was 1.1 ml (range 0.1 to 3.2 ml). Calculation of right and left ventricular stroke volumes from data from cine CT were highly reproducible. Intraobserver variability in measurements of right ventricular stroke volume (r = 1.0, slope = 0.99, y intercept = 0.19 ml) and left ventricular stroke volume (r = 1.0, slope = 1.02, y intercept = -0.21 ml) was minimal. Interobserver variability in measurements of right ventricular stroke volume (r = .98, slope = 0.90, y intercept = 1.66 ml) and left ventricular stroke volume (r = .99, slope = 0.97, y intercept = -0.02 ml) was likewise minimal. Thus, precise and highly reproducible measurements of right and left ventricular stroke volumes can be obtained with cine CT.