POSTNATAL DEVELOPMENT OF THE CUTANEOUS FLEXOR REFLEX: COMPARATIVE STUDY OF PRETERM INFANTS AND NEWBORN RAT PUPS
POSTNATAL DEVELOPMENT OF THE CUTANEOUS FLEXOR REFLEX: COMPARATIVE STUDY OF PRETERM INFANTS AND NEWBORN RAT PUPS
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产后皮肤屈肌反射的发育：早产儿和新生大鼠幼崽的比较研究
DOI：
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发表时间：
1988
影响因子：
3.8
通讯作者：
Neil MacIntosh
中科院分区：
文献类型：
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作者：
Maria FitzgeraId;A. Shaw;Neil MacIntosh
皮肤屈肌反射阈值已被用作躯体感觉功能的测量：作者测量了早产儿和新生大鼠幼仔的阈值。小于30周龄的早产儿的PCA阈值非常低，小于1.0g，但到37.5+周龄时，PCA阈值与正常足月儿相当，尽管这些阈值仍远低于成人水平。新生大鼠幼崽也有非常低的屈肌反射阈值，直到出生后四周才接近成年水平。反复刺激早产儿的足部导致屈曲反射敏感化，持续到PCA约32周。在这个年龄之后，重复的刺激导致了习惯化，就像在成年人中观察到的那样。致敏作用也发生在新生大鼠幼崽中，其在出生后四周改变为习惯性。结果表明，脊髓反射的敏感性皮肤输入的新生儿，有人认为，这是由于缺乏抑制控制在未成熟的脊髓。
Cutaneous flexor reflex thresholds have been used as a measure of somatosensory function: the authors measured threshold in preterm infants and newborn rat pups. Preterm infants of less than 30 weeks postconceptional age (PCA) had very low thresholds of less than 1·0g, but by 37·5+ weeks PCA thresholds were equivalent to those in normal term babies, although these are still well below adult levels. Newborn rat pups also have very low flexor reflex thresholds, which do not approach adult levels until four postnatal weeks. Repeated stimulation of the foot in preterm babies resulted in sensitization of the flexion reflex up to about 32 weeks PCA. After that age repeated stimulation resulted in habituation, as is observed in the adult. Sensitization also occurred in newborn rat pups, which changed at four postnatal weeks to habituation. The results demonstrate, the sensitivity of spinal reflexes to cutaneous inputs in the neonate and it is argued that this results from lack of inhibitory control in the immature spinal cord.