Virus-neutralizing activity, serologic heterogeneity, and retrovirus isolation from homosexual men in the Los Angeles area.
Virus-neutralizing activity, serologic heterogeneity, and retrovirus isolation from homosexual men in the Los Angeles area.
复制标题
洛杉矶地区男同性恋者的病毒中和活性、血清学异质性和逆转录病毒分离。
DOI：
10.1016/0042-6822(86)90260-6
复制
发表时间：
1986
期刊：
影响因子：
3.7
通讯作者：
Levine,AM
中科院分区：
文献类型：
--
作者：
Rasheed,S;Norman,GL;Gill,PS;Meyer,PR;Cheng,L;Levine,AM
人类逆转录病毒与包括静脉注射吸毒者、血友病患者和同性恋者在内的高危人群中获得性免疫缺陷综合征(AIDS)的发展存在因果关系。除了典型的艾滋病，同性恋者还会患上持续性全身性淋巴结病(PGL)，这被认为是艾滋病相关复合体(ARC)的一部分。我们已经从PGL、AIDS或ARC患者身上分离出70株与人类T淋巴细胞嗜T细胞病毒III型(HTLV-III)相关的逆转录病毒。对这些患者血清的分析表明，抗体滴度及其对各种HTLV-III病毒蛋白的反应性在血清学上具有高度的异质性。此外，我们在检测的来自PGL或AIDS患者的大约50%的血清样本中检测到了病毒中和抗体。这是洛杉矶一家机构对100多名患者进行研究的第一份全面的病毒学和血清学报告。
Human retroviruses have been causally associated with the development of the acquired immune deficiency syndrome (AIDS) in groups of individuals at high risk including intravenous drug users, hemophiliacs, and homosexual men. Aside from classic AIDS, homosexual men also develop persistent generalized lymphadenopathy (PGL) which is considered a part of the AIDS-related complex (ARC). We have isolated 70 strains of retroviruses related to human T-lymphotropic viruses type III (HTLV-III) from patients with PGL, AIDS, or ARC. Analyses of sera from these patients indicated a high degree of serologic heterogeneity in the antibody titers and their reactivities toward various HTLV-III viral proteins. In addition, we have detected virus-neutralizing antibodies in approximately 50% of the serum samples tested from patients with PGL or AIDS. This is the first comprehensive virologic and serologic report on more than 100 patients studied at one institution in Los Angeles.