Activatable Core-Shell Metallofullerene: An Efficient Nanoplatform for Bimodal Sensing of Glutathione
Activatable Core-Shell Metallofullerene: An Efficient Nanoplatform for Bimodal Sensing of Glutathione
复制标题
可激活核壳金属富勒烯：谷胱甘肽双峰传感的高效纳米平台
DOI：
10.1021/acsami.9b18807
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发表时间：
2019
影响因子：
9.5
通讯作者：
Ting Cai
中科院分区：
文献类型：
--
作者：
Yayun Peng;Chao Ye;Runqi Yan;Yuzhu Lei;Deju Ye;Hao Hong;Ting Cai
金属富勒烯作为一种潜在的新型无创高弛豫磁共振造影剂引起了人们的广泛关注。然而，金属富勒烯作为刺激响应生物传感器监测生物过程的应用仍然很少。本文中，锰-富勒烯核-壳纳米复合材料通过简单的一锅法制备，以实现GSH可激活的磁共振/荧光双峰成像功能。该纳米复合材料最初具有FRET诱导的淬灭荧光，和耐水刺激的低T1-MRI对比度。当暴露于GSH时，外MnO 2壳的塌陷导致纳米探针的重建，随后导致荧光恢复和纵向（T1）弛豫增强（基于Mn离子，在0.5 T下r1值高达29.8 mM-1 s-1）。我们的工作表明，使用富勒烯来制造可激活的GSH分子成像探针的可行性，这可能会促进新的富勒烯为基础的刺激响应的多模态探针的检测和调节特定的生物过程中体内的发展。
Metallofullerenes have attracted considerable attention as potential novel noninvasive high-relaxivity magnetic resonance contrast agents. However, the applications of metallofullerenes as stimuli-responsive biosensors to monitor biological processes are still scarce. Herein, manganese-fullerenes core–shell nanocomposites are prepared via a facile one-pot approach to achieve GSH-activatable magnetic resonance/fluorescence bimodal imaging functions. The nanocomposites initially have a FRET-induced quenched fluorescence, and water-resisting stimulated lowT1-MRI contrast. Upon exposure to GSH, collapse of the outer MnO2shell led to reconstruction of the nanoprobes and subsequently resulted in multicolor fluorescence recovery and longitudinal (T1) relaxivity enhancement (r1value up to 29.8 mM–1s–1at 0.5 T based on Mn ion). Our work demonstrates feasibility of using fullerenes to fabricate activatable probes for molecular imaging of GSH, which may promote the development of new fullerene-based stimuli-responsive multimodal probes for the detection and regulation of particular biological processes in vivo.