The fibroblast growth factor family: structural and biological properties.
The fibroblast growth factor family: structural and biological properties.
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DOI：
10.1016/0955-2235(89)90012-4
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
Klagsbrun, M
中科院分区：
文献类型：
--
作者：
Klagsbrun, M
本文综述了成纤维细胞生长因子家族的结构和生物学特性。碱性成纤维细胞生长因子(BFGF)和酸性成纤维细胞生长因子(AFGF)是该家族最具特征的成员。碱性成纤维细胞生长因子和碱性成纤维细胞生长因子是细胞增殖、运动和分化的强有力的调节剂。它们也是体内强有力的血管生成因子。综述中讨论了一些重要的生物学特性，包括碱性成纤维细胞生长因子和碱性成纤维细胞生长因子对肝素的亲和力，它们在培养中缺乏分泌，以及它们与细胞外基质的关系。最近，一些癌基因已经被鉴定出来，它们与bFGFs和aFGFs有40%-50%的同源性。它们包括INT-2、hst、K-FGFs和FGF5。并对这些与成纤维细胞生长因子相关的癌基因的结构和生物学特性进行了讨论。
This article summarizes the structural and biological properties of the family of fibroblast growth factors (FGF). Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. bFGF and aFGF are potent modulators of cell proliferation, motility and differentiation. They are also potent angiogenesis factors in vivo. Some of the important biological characteristics of bFGF and aFGF discussed in the review include the affinity of bFGF and aFGF for heparin, their lack of secretion in culture and their association with extracellular matrix. Recently, several oncogenes, 40-50% homologous in sequence to bFGF and aFGF have been identified. These include int-2, hst, K-fgf and FGF-5. The structural and biological properties of these FGF-related oncogenes are also discussed.