Asthma: Is it due to an abnormal airway smooth muscle cell?
Asthma: Is it due to an abnormal airway smooth muscle cell?
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DOI：
10.1164/rccm.200501-082pp
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发表时间：
2006-08-15
影响因子：
24.7
通讯作者：
Roth, Michael
中科院分区：
文献类型：
--
作者：
Borger, Peter;Tamm, Michael;Roth, Michael
哮喘是一种在西方化国家高度流行的呼吸道疾病，病因不明。通常，哮喘与特应性有关，但并非所有特应性个体都患有哮喘。一些哮喘患者长大后症状就消失了，而其他许多人则在晚年患上哮喘。还有一些患者一生都饱受哮喘的折磨。我们如何解释这些不同的模式呢？也许，哮喘应该被视为一组具有相似病理的疾病的临床表现，因为有一个共同的因素。从肺的角度来看，我们提出气道平滑肌（ASM）细胞的异常表型可能足以解释哮喘的病理。我们将讨论异常的ASM细胞是哮喘发展的先决条件。我们的假设是，C/EBP α（一种抑制炎症和增殖反应的关键蛋白）水平不足，使ASM细胞具有激活的表型，更容易受到有丝分裂和收缩刺激。
Asthma is an airway disease highly prevalent in westernized countries and of unknown etiology. Often, asthma is associated with atopy, but not all atopic individuals have asthma. Some patients with asthma outgrow symptoms, whereas many others acquire asthma later in life. Still other patients suffer from asthma their entire life. How can we explain these different patterns? It may be that asthma should be regarded as the clinical manifestation of a group of diseases with similar pathology due to a common factor. In this Pulmonary Perspective, we propose that an aberrant phenotype of airway smooth muscle (ASM) cells could be sufficient to explain the pathology of asthma. We will argue an abnormal ASM cell is a prerequisite to the development of asthma. Our postulate is that inadequate levels of C/EBP alpha, a protein that is pivotal for the suppression of both inflammation and proliferation responses, confer on ASM cells an activated phenotype that is more susceptible to mitogenic and contractile stimuli.