Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator.
Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator.
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DOI：
10.1021/acsnano.9b03912
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发表时间：
2019-09
期刊：
影响因子：
17.1
通讯作者：
Guang Yao;Dawei Jiang;Jun Li;L. Kang;Sihong Chen;Yin Long;Yizhan Wang;Peng Huang;Yuan Lin;W. Cai;Xudong Wang
中科院分区：
文献类型：
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作者：
Guang Yao;Dawei Jiang;Jun Li;L. Kang;Sihong Chen;Yin Long;Yizhan Wang;Peng Huang;Yuan Lin;W. Cai;Xudong Wang
脱发是困扰人类的一种常见而令人痛苦的症状。各种药物和非药物治疗已被广泛研究，以达到所需的效果，头发再生。作为一种非药理学物理手段，生理学上适宜的交变电场在再生组织工程领域起着关键作用。本文设计了一种通用的运动激活的可穿戴式电刺激装置，该装置可以通过随机的身体运动来有效地促进毛发再生。从Sprague-Dawley大鼠和裸鼠中获得了显著促进的毛发再生结果。与常规药物治疗相比，使用该装置时，在Sprague-Dawley大鼠上观察到毛囊密度更高，毛干长度更长。该装置还可以改善血管内皮生长因子和角质形成细胞生长因子的分泌，从而减轻毛发角蛋白紊乱，增加毛囊数量，促进遗传缺陷裸鼠的毛发再生。这项工作提供了一个有效的毛发再生策略的上下文中的非药理学自供电的可穿戴电子设备。
Hair loss, a common and distressing symptom, has been plaguing humans. Various pharmacological and nonpharmacological treatments have been widely studied to achieve the desired effect for hair regeneration. As a nonpharmacological physical approach, physiologically appropriate alternating electric field plays a key role in the field of regenerative tissue engineering. Here, a universal motion-activated and wearable electric stimulation device that can effectively promote hair regeneration via random body motions was designed. Significantly facilitated hair regeneration results were obtained from Sprague-Dawley rats and nude mice. Higher hair follicle density and longer hair shaft length were observed on Sprague-Dawley rats when the device was employed compared to conventional pharmacological treatments. The device can also improve the secretion of vascular endothelial growth factor and keratinocyte growth factor and thereby alleviate hair keratin disorder, increase the number of hair follicles, and promote hair regeneration on genetically defective nude mice. This work provides an effective hair regeneration strategy in the context of a nonpharmacological self-powered wearable electronic device.