Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients.
Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients.
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DOI：
10.1002/acr.23210
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发表时间：
2017-12
影响因子：
4.7
通讯作者：
Fiorentino DF
中科院分区：
文献类型：
--
作者：
Rogers A;Chung L;Li S;Casciola-Rosen L;Fiorentino DF
To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with anti-NXP-2 antibodies. We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. Electronic chart review employing a keyword search strategy was performed to collect clinical and laboratory data. Anti-NXP-2 antibodies were assayed by immunoprecipitation using NXP-2 produced by in vitro transcription/translation. Antibodies to NXP-2 were detected in 20 (11%) of the 178 patients. Anti-NXP-2 antibodies were associated with male gender (50% vs. 25%, p=0.02), dysphagia (74% vs. 39%, p=0.006), myalgia (89% vs. 52%, p=0.002), peripheral edema (35% vs. 11%, p=0.016), and calcinosis (37% vs. 11%, p=0.007). These patients were less likely to be clinically amyopathic (5% vs 23%, p=0.08). Five of the 20 patients with NXP-2 antibodies (25%) had an associated internal malignancy. No other cutaneous characteristics were associated with anti-NXP-2 antibodies except a decreased frequency of Gottron’s sign (44% vs. 75%, p=0.012) and the fact that these patients were more likely to have mild skin disease. Dermatomyositis patients with anti-NXP2 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema and significant dysphagia despite having milder inflammatory skin disease.
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影响因子：
10.9
作者：
Valenzuela, Antonia;Chung, Lorinda;Casciola-Rosen, Livia;Fiorentino, David
通讯作者：
Fiorentino, David
影响因子：
3.7
作者：
Mugii N;Hasegawa M;Matsushita T;Hamaguchi Y;Oohata S;Okita H;Yahata T;Someya F;Inoue K;Murono S;Fujimoto M;Takehara K
通讯作者：
Takehara K
DOI：
10.1111/bjd.13915
发表时间：
2015-10
期刊：
The British journal of dermatology
影响因子：
--
作者：
Anyanwu CO;Fiorentino DF;Chung L;Dzuong C;Wang Y;Okawa J;Carr K;Propert KJ;Werth VP
通讯作者：
Werth VP
影响因子：
158.5
作者：
BOHAN, A;PETER, JB
通讯作者：
PETER, JB
影响因子：
5.5
作者：
Tansley, Sarah L.;Betteridge, Zoe E.;McHugh, Neil J.
通讯作者：
McHugh, Neil J.