L-methionine-induced alterations in molecular signatures in MCF-7 and LNCaP cancer cells.
L-methionine-induced alterations in molecular signatures in MCF-7 and LNCaP cancer cells.
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DOI：
10.1007/s00432-010-0897-5
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发表时间：
2011-03
影响因子：
3.6
通讯作者：
Bosland, Maarten C.
中科院分区：
文献类型：
--
作者：
Benavides, Maximo A.;Hu, Dong;Baraoidan, Marie Kristine;Bruno, Annette;Du, Pan;Lin, Simon;Yang, Wancai;Bland, Kirby I.;Grizzle, William E.;Bosland, Maarten C.
蛋氨酸抑制乳腺癌和前列腺癌细胞的增殖。在这里，我们确定了l -蛋氨酸对这些细胞系功能分子特征的影响。用l -蛋氨酸（5 mg/ml）处理MCF-7和LNCaP细胞72 h，通过三次实验中15814个探针的微阵列分析来检测这些细胞的分子特征变化。在LNCaP细胞中，有325个基因被蛋氨酸上调，517个基因被下调。在MCF-7细胞中，86个基因上调，135个基因下调。在两种细胞系中，蛋氨酸对98个基因的表达方向一致，对5个基因的表达方向相反。一些上调的基因编码参与细胞氧化还原调节的蛋白质，表明蛋氨酸可能增强抗氧化机制。许多下调的基因属于蛋白激酶家族，可能与蛋氨酸对乳腺癌和前列腺癌细胞的抗增殖作用有关。
Methionine inhibits proliferation of breast and prostate cancer cells. Here, we determined the inXuence of L-methionine on functional molecular signatures in these cell lines. MCF-7 and LNCaP cells were treated with L-methionine (5 mg/ml) for 72 h. Changes in molecular signatures of these cells were examined by microarray analysis of 15,814 probes in triplicate experiments. In LNCaP cells, 325 genes were up-regulated by methionine, and 517 genes down-regulated. In MCF-7 cells, 86 genes were up-regulated and 135 genes down-regulated. Ninety-eight genes were regulated in the same direction by methionine in both cells lines, and five other genes were changed in expression in opposite directions. Several of the up-regulated genes encode proteins involved in cellular redox regulation, suggesting that methionine may enhance antioxidant mechanisms. Many of the down-regulated genes belong to protein kinase families that may be related to the anti-proliferative effects of methionine on breast and prostate cancer cells.
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影响因子：
4.8
作者：
Bello, RI;Gómez-Díaz, C;Villalba, JM
通讯作者：
Villalba, JM
影响因子：
4.2
作者：
SantaCruz, KS;Yazlovitskaya, E;DeCarli, C
通讯作者：
DeCarli, C
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
30.8
作者：
Fagerholm, Rainer;Hofstetter, Barbara;Nevanlinna, Heli
通讯作者：
Nevanlinna, Heli
影响因子：
3
作者：
Benavides, Maximo A.;Oelschlager, Denise K.;Grizzle, William E.
通讯作者：
Grizzle, William E.