Two-stage Analysis for Gene-Environment Interaction Utilizing Both Case-Only and Family-Based Analysis
Two-stage Analysis for Gene-Environment Interaction Utilizing Both Case-Only and Family-Based Analysis
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DOI：
10.1002/gepi.20357
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发表时间：
2009-02-01
影响因子：
2.1
通讯作者：
Liu, Huimei
中科院分区：
文献类型：
--
作者：
Chen, Yi-Hau;Lin, Hui-Wen;Liu, Huimei
纯病例研究和家系研究是检测基因-环境交互作用的两种常用研究设计。众所周知，仅病例分析是有效的，但其有效性依赖于研究群体中基因-环境独立性的假设。相比之下，基于家庭的分析是强大的违反这样一个假设，但效率较低。我们提出了一个两阶段的研究设计，用于检测基因-环境相互作用，其中仅在第一阶段进行病例研究，在第二阶段对第一阶段病例样本的随机子样本以及他们的父母/未受影响的兄弟姐妹进行病例-父母/病例-兄弟姐妹研究。统计推断程序的建议，两阶段的研究设计，它不仅保留了稳健性的家庭为基础的分析，但也利用信息，从仅病例分析，以提高估计效率和检验能力。仿真结果表明，所提出的策略的鲁棒性和效率。Genet.流行病学33：95-104，2009. (C)2008 Wiley-Liss，Inc.
The case-only study and family-based study are two popular study designs for detecting gene-environment interactions. It is well known that the case-only analysis is efficient, but its validity relies crucially on the assumption of gene-environment independence in the study population. In contrast, the family-based analysis is robust to the violation of such an assumption, but is less efficient. We propose a two-stage study design for detecting gene-environment interactions, where a case-only study is performed at the first stage, and a case-parent/case-sibling study is performed at the second stage on a random subsample of the first-stage case sample as well as their parents/unaffected siblings. Statistical inference procedures are developed for the proposed two-stage study designs, which not only preserve the robustness property of the family-based analysis, but also utilize information from the case-only analysis to enhance estimation efficiency and testing power. Simulation results reveal both the robustness and efficiency of the proposed strategies. Genet. Epidemiol. 33:95-104, 2009. (C) 2008 Wiley-Liss, Inc.