Network architecture, receptive fields, and neuromodulation: Computational and functional implications of cholinergic modulation in primary auditory cortex
Network architecture, receptive fields, and neuromodulation: Computational and functional implications of cholinergic modulation in primary auditory cortex
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DOI：
10.1152/jn.00459.2006
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发表时间：
2006-12-01
影响因子：
2.5
通讯作者：
Sen, Kamal
中科院分区：
文献类型：
--
作者：
Soto, Gabriel;Kopell, Nancy;Sen, Kamal
听觉皮质加工的两个基本问题是丘脑皮质与皮质内回路在形成初级听觉皮质（ACx）反应特性中的相对重要性，以及神经调节剂对这些回路的影响如何影响网络和感受野特性的动态变化，从而增强信号处理和适应行为。为了研究这些问题，我们开发了人工智能的第三和第四层（LIII/IV）的计算模型，受解剖和生理数据的约束。我们关注局部和全局皮质结构如何塑造皮质细胞的感受野（RFs），以及不同的已建立的胆碱能对皮质网络的影响如何重塑ACx细胞的频率调谐特性。我们确定了强烈影响模型皮质神经元调谐曲线的关键丘脑皮质和皮质内回路，并且对胆碱能调节也很敏感。然后，我们研究了网络参数的不同胆碱能调节如何改变我们的模型细胞的调谐特性，并提出了两种不同的机制：一种是皮质内（涉及毒蕈碱受体），一种是丘脑皮质（涉及尼古丁受体），这可能与ACx的快速可塑性有关，正如Fritz和同事最近在一项研究中所报道的那样。
Two fundamental issues in auditory cortical processing are the relative importance of thalamocortical versus intracortical circuits in shaping response properties in primary auditory cortex (ACx), and how the effects of neuromodulators on these circuits affect dynamic changes in network and receptive field properties that enhance signal processing and adaptive behavior. To investigate these issues, we developed a computational model of layers III and IV (LIII/IV) of AI, constrained by anatomical and physiological data. We focus on how the local and global cortical architecture shape receptive fields (RFs) of cortical cells and on how different well-established cholinergic effects on the cortical network reshape frequency-tuning properties of cells in ACx. We identify key thalamocortical and intracortical circuits that strongly affect tuning curves of model cortical neurons and are also sensitive to cholinergic modulation. We then study how differential cholinergic modulation of network parameters change the tuning properties of our model cells and propose two different mechanisms: one intracortical (involving muscarinic receptors) and one thalamocortical (involving nicotinic receptors), which may be involved in rapid plasticity in ACx, as recently reported in a study by Fritz and coworkers.