Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: A proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material
Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: A proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material
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DOI：
10.1016/s0165-0270(97)00079-4
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发表时间：
1997-09-05
影响因子：
3
通讯作者：
Ravid, R
中科院分区：
文献类型：
--
作者：
Danscher, G;Jensen, KB;Ravid, R
锌已被认为是阿尔茨海默病(AD)神经病理的一个因素，但关于AD大脑中锌含量的共识尚未建立。本研究采用多元素PIXE法测定AD患者和正常对照组脑组织冰冻切片中锌的含量。与年龄匹配的对照组相比，阿尔茨海默病患者的海马区和杏仁核区锌含量增加。仪器PIXE分析没有显示锌的变化是由于富锌(ZEN)神经元外周的锌变化，即突触小泡中的锌离子，还是由于与大分子紧密结合的锌量的变化。我们假设锌水平的增加是由Zen末端数量的增加引起的。这种增加可能是大脑病变区域禅宗终末萌芽的结果。(C)1997年爱思唯尔科学公司。
Zinc has been implicated as a contributing cause of the neuropathology of Alzheimer's disease (AD), but consensus on the zinc content of AD brains has not yet been established. In the present study, multi-element PIXE was used to measure zinc in cryostat sections of brain tissue from AD patients and from normal control subjects. Compared to their age-matched controls, the AD patients showed an increase in zinc in the hippocampal and amygdalar regions. The instrumental PIXE assays do not show whether the zinc changes are due to altered zinc in the boutons of Zinc-ENriched (ZEN) neurons, i.e., zinc ions in synaptic vesicles, or to changes in the amount of zinc tightly bound to macromolecules. We hypothesise that the increased zinc level is caused by an increase in the amount of ZEN terminals. Such an increase could be the result of a sprout of ZEN terminals in diseased areas of the brain. (C) 1997 Elsevier Science B.V.