Mathematical Analysis of a Kinetic Model for Cell Movement in Network Tissues

Mathematical Analysis of a Kinetic Model for Cell Movement in Network Tissues
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网络组织中细胞运动动力学模型的数学分析

DOI:
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发表时间:
2008
期刊:
影响因子:
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通讯作者:
Zhian Wang
Zhian Wang
中科院分区:
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文献类型:
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作者:
T. Hillen;P. Hinow;Zhian Wang

文献摘要

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间充质运动描述了细胞在生物组织中的运动形成 通过光纤网络。一个重要的例子是肿瘤细胞通过 转移形成过程中的胶原网络。我们调查的 提出的间充质运动模型。希伦在[14]在更高 尺寸.我们将问题表述为Banach空间中的演化方程 的测度值函数,并使用半群理论的方法来证明 温和解和经典解的整体存在性。我们研究的稳态 模型,并表明网络型模式存在的稳定状态。为 的情况下,恒定的纤维分布,我们找到了一个明确的解决方案,我们证明 收敛到抛物线极限。
Mesenchymal motion describes the movement of cells in biological tissues formed by fibre networks. An important example is the migration of tumour cells through collagen networks during the process of metastasis formation. We investigate the mesenchymal motion model proposed by T. Hillen in [14] in higher dimensions. We formulate the problem as an evolution equation in a Banach space of measure-valued functions and use methods from semigroup theory to show the global existence of mild and classical solutions. We investigate steady states of the model and show that patterns of network type exist as steady states. For the case of constant fibre distribution, we find an explicit solution and we prove the convergence to the parabolic limit.