Daytime sleepiness in mild and moderate Alzheimer's disease and its relationship with cognitive impairment
Daytime sleepiness in mild and moderate Alzheimer's disease and its relationship with cognitive impairment
复制标题
轻度和中度阿尔茨海默氏症患者的白天嗜睡及其与认知障碍的关系
DOI：
10.1111/j.1365-2869.2005.00462.x
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发表时间：
2005-09-01
影响因子：
4.4
通讯作者：
Murri, L
中科院分区：
文献类型：
--
作者：
Bonanni, E;Maestri, M;Murri, L
在晚期阿尔茨海默病（AD）患者中，白天入睡的倾向增加，夜间清醒的倾向增加。本研究的目的是评估一组轻度/中度AD患者的日间睡眠倾向，并将其与认知障碍联系起来。对20例符合NINCDS-ADRDA可能AD标准的无药AD患者进行了评估。根据临床痴呆评分将受试者分为轻度（CDRI, n = 11）和中度（CDR2, n = 9）痴呆患者。以12名健康受试者为对照。受试者在前一晚通过多导睡眠记录仪评估夜间睡眠模式后，进行多次睡眠潜伏期测试（MSLT）评估。两组AD患者均表现出较高水平的日间嗜睡，这在平均日间睡眠潜伏期（MDSL）（对照与CDRI和CDR2， CDRI与CDR2）以及10:00和12:00小时小睡（对照与CDRI，对照与CDR2）方面具有统计学意义。在整个AD患者组中，MDSL与MMSE、De Renzi’s Token测试、言语流畅性、言语数字广度、故事回忆、Raven’s Progressive Matrices、Weigl测试和Benton’s三维测试显著相关。这些数据表明，通过客观神经生理学技术检测到的轻度/中度AD患者白天睡眠倾向也会增加。
The increased tendency to fall asleep during the daytime together with increased wakefulness during the night has been demonstrated in patients with advanced Alzheimer's disease (AD). The aim of this study was to assess daytime sleep propensity in a cohort of patients with mild/moderate AD and to correlate it with cognitive impairment. Twenty drug-free AD patients meeting the NINCDS-ADRDA criteria for probable AD were evaluated. According to their Clinical Dementia Rating scores, subjects were classified into mild (CDRI; n = 11) and moderate (CDR2; n = 9) dementia patients. A group of 12 healthy subjects was taken as controls. The subjects were evaluated by the multiple sleep latency test (MSLT) after their nocturnal sleep pattern had been assessed by a polysomnographic recording throughout the night before. Both groups of AD patients showed a higher level of daytime sleepiness, which was statistically significant for mean daytime sleep latency (MDSL) (controls versus CDRI and versus CDR2, CDRI versus CDR2) and for 10:00 and 12:00 hour naps (controls versus CDRI, controls versus CDR2). In the entire group of AD patients, MDSL was significantly related with MMSE, De Renzi's Token test, verbal fluency, verbal digit span, story recall, Raven's Progressive Matrices, Weigl test and Benton's three-dimensional test. These data indicate that an increased sleep propensity during daytime occurs also in patients with mild/moderate AD detected by objective neurophysiological techniques.