Generation of neuronal variability and complexity
Generation of neuronal variability and complexity
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DOI：
10.1038/nature04959
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发表时间：
2006-06-28
期刊：
影响因子：
64.8
通讯作者：
Gage, Fred H.
中科院分区：
文献类型：
--
作者：
Muotri, Alysson R.;Gage, Fred H.
从干细胞中得出的专门分化神经元的生产已被提议作为再生医学的革命性技术。然而，到目前为止，很少有特定神经元细胞分化的例子。尽管在其他情况下，干细胞组织更换似乎很简单，但神经系统的高度复杂性大大增加了组织置换的挑战。了解神经多样化的机制不仅与治疗目的有关，而且还可能阐明人类观察到的认知能力，人格特质和精神病的差异。
The production of specialized differentiated neurons derived from stem cells has been proposed as a revolutionary technology for regenerative medicine. However, few examples of specific neuronal cell differentiation have been described so far. Although stem-cell tissue replacement might be seemingly straightforward in other cases, the high degree of complexity of the nervous system raises the challenge of tissue replacement substantially. Understanding mechanisms of neuronal diversification will not only be relevant for therapeutic purposes but might also shed light on the differences in cognitive abilities, personality traits and psychiatric conditions observed in humans.