Race and Sex Differences of Long-Term Blood Pressure Profiles From Childhood and Adult Hypertension: The Bogalusa Heart Study.
Race and Sex Differences of Long-Term Blood Pressure Profiles From Childhood and Adult Hypertension: The Bogalusa Heart Study.
复制标题
儿童和成人高血压长期血压曲线的种族和性别差异 Bogalusa 心脏研究
DOI：
10.1161/hypertensionaha.117.09537
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Shen W;Zhang T;Li S;Zhang H;Xi B;Shen H;Fernandez C;Bazzano L;He J;Chen W
This study aims to characterize longitudinal blood pressure (BP) trajectories from childhood in black-white and gender groups and examine the association between childhood level-independent trajectories of BP and adult hypertension. The longitudinal cohort consisted of 2,732 adults who had body mass index and BP measured 4–15 times from childhood (4–19 years) to adulthood (20–51 years). Model-estimated levels and linear slopes of BP and BMI at childhood age points were calculated at one-year intervals using the growth curve parameters and their first derivatives, respectively. Linear and nonlinear curve parameters differed significantly between race-gender groups; BP levels showed race and gender differences from age 15 years onwards. Hypertensives had higher long-term BP levels than normotensives in race-gender groups. Although linear and nonlinear slope parameters of BP were race- and gender-specific, they differed consistently, significantly between hypertension and normotension groups. BP trajectories during young adulthood (20–35 years) were significantly greater in hypertensives than in normotensives; however, the trajectories during middle-aged adulthood (36–51 years) were significantly smaller in hypertensives than in normotensives. Level-independent linear slopes of systolic BP showed significantly negative associations (odds ratio=0.50~0.76, p<0.001) during pre-puberty period (4–11 years) but significantly positive associations (odd ratio=1.44~2.80, p<0.001) during the puberty period (13–19 years) with adult hypertension, adjusting for covariates. These associations were consistent across race-gender groups. These observations indicate that adult hypertension originates in childhood, with different longitudinal BP trajectory profiles during young and middle-aged adulthood in black-white and gender groups. Puberty is a crucial period for the development of hypertension in later life.
