The human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV interact with similar epitopes on their cellular receptor, the CD4 molecule.
The human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV interact with similar epitopes on their cellular receptor, the CD4 molecule.
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人类和猿猴免疫缺陷病毒 HIV-1、HIV-2 和 SIV 与其细胞受体 CD4 分子上的相似表位相互作用。
DOI：
10.1097/00002030-198804000-00005
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发表时间：
1988
期刊：
影响因子：
3.8
通讯作者：
D. Klatzmann
中科院分区：
文献类型：
--
作者：
Q. Sattentau;P. Clapham;R. Weiss;P. Beverley;L. Montagnier;M. F. Alhalabi;J. Gluckmann;D. Klatzmann
HIV-1的细胞受体是白细胞分化抗原CD4。阻断HIV-1的感染可以通过单克隆抗体（mab）来实现，但不是所有抗原的表位。通过抑制病毒感染、阻断合胞体形成和用一组CD4单克隆抗体抑制假型感染，我们证明HIV-1、HIV-2和猴免疫缺陷病毒（SIV）分离株具有相同的细胞受体，即CD4糖蛋白。研究还表明，该分子的非常相似的表位参与病毒的结合。我们从这些数据推断，这些病毒的结合位点是高度保守的区域，因此可能是潜在疫苗的良好靶点。此外，我们发现CD4的细胞表面表达在所有病毒感染细胞系后都有相似的调节。
The cellular receptor for HIV-1 is the leucocyte differentiation antigen, CD4. Blocking of HIV-1 infectivity can be achieved with monoclonal antibodies (MAbs) to some, but not all epitopes of this antigen. We demonstrate here, by inhibition of virus infection, blocking of syncytium formation and inhibition of pseudotype infection with a panel of CD4 MAbs, that HIV-1, HIV-2 and simian immunodeficiency virus (SIV) isolates share the same cellular receptor, the CD4 glycoprotein. It is also shown that very similar epitopes of this molecule are involved in virus binding. We infer from these data that the binding sites on these viruses are highly conserved regions, and may therefore make good targets for potential vaccines. In addition, we show that cell surface expression of CD4 is similarly modulated after infection of cell lines by all the viruses.