Synthesis of novel push-pull-type solvatochromic 2′-deoxyguanosine derivatives with longer wavelength emission
Synthesis of novel push-pull-type solvatochromic 2′-deoxyguanosine derivatives with longer wavelength emission
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DOI：
10.1016/j.tetlet.2010.03.012
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发表时间：
2010-05-12
影响因子：
1.8
通讯作者：
Saito, Isao
中科院分区：
文献类型：
--
作者：
Saito, Yoshio;Suzuki, Azusa;Saito, Isao
我们合成了新的推挽型荧光鸟苷衍生物，（CN）G和（Ac）G，其中含有1，6-和2，7-二取代芘发色团。1，6-二取代芘衍生物1，6-（CN）G（3b）和1，6-（Ac）G（3c）在较长波长（近似于540 nm）处具有高溶致变色荧光发射。环境敏感的脱氧鸟苷类荧光化合物3b和3c可作为核酸结构研究和分子诊断的有力工具。(C)2010爱思唯尔有限公司版权所有。
We synthesized novel push-pull-type fluorescent guanosine derivatives, (CN)G and (Ac)G containing 1,6- and 2,7-disubstituted pyrene chromophores. 1,6-Disubstituted pyrene derivatives, 1,6-(CN)G (3b) and 1,6-(Ac)G (3c), exhibited highly solvatochromic fluorescence emission at longer wavelength (similar to 540 nm). The environmentally sensitive fluorescent deoxyguanosines such as 3b and 3c can be used as powerful tools for structural studies of nucleic acids and molecular diagnostics. (C) 2010 Elsevier Ltd. All rights reserved.