Stem cells in bone diseases: current clinical practice
Stem cells in bone diseases: current clinical practice
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DOI：
10.1093/bmb/ldr035
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发表时间：
2011-09-01
影响因子：
6.7
通讯作者：
Liebergall, Meir
中科院分区：
文献类型：
--
作者：
Beyth, Shaul;Schroeder, Josh;Liebergall, Meir
简介：骨是干细胞治疗的明显候选组织。本综述提供了一个更新现有的干细胞为基础的临床治疗骨pathology.Sources的数据：进行了系统的计算机文献检索。2011年2月10日访问了以下数据库：NIH临床试验数据库，PubMed，奥维德和科克伦评论。一致的领域：干细胞治疗为骨骼疾病提供了新的选择，包括获得性和遗传性。争议的领域：仍然没有就“间充质干细胞”的确切定义达成一致。因此，扩大培养的效果和同种异体移植的可行性是很难判断的。生长点：基于临床前研究的良好基础，最近出现了基于干细胞的治疗和方案。适时开展研究的领域：为了建立和发展骨疾病的干细胞治疗，需要精心设计的前瞻性临床试验。
Introduction: Bone is an obvious candidate tissue for stem cell therapy. This review provides an update of existing stem cell-based clinical treatments for bone pathologies.Sources of data: A systematic computerized literature search was conducted. The following databases were accessed on 10 February 2011: NIH clinical trials database, PubMed, Ovid and Cochrane Reviews.Areas of agreement: Stem cell therapy offers new options for bone conditions, both acquired and inherited.Areas of controversy: There is still no agreement on the exact definition of 'mesenchymal stem cells'. Consequently, it is difficult to appreciate the effect of culture expansion and the feasibility of allogeneic transplantation.Growing points: Based on the sound foundations of pre-clinical research, stem cell-based treatments and protocols have recently emerged.Areas timely for developing research: Well-designed prospective clinical trials are needed in order to establish and develop stem cell therapy for bone diseases.