Androgen receptor gene polymorphisms are associated with aggression in Japanese Akita Inu
Androgen receptor gene polymorphisms are associated with aggression in Japanese Akita Inu
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DOI：
10.1098/rsbl.2011.0087
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发表时间：
2011-10-23
期刊：
影响因子：
3.3
通讯作者：
Hasegawa, Toshikazu
中科院分区：
文献类型：
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作者：
Konno, Akitsugu;Inoue-Murayama, Miho;Hasegawa, Toshikazu
我们测试了犬雄激素受体（AR）基因中不同数量的串联重复序列与日本秋田犬性格差异之间的关联。使用从 171 只狗获得的基因组 DNA 对 AR 基因外显子 1 中编码谷氨酰胺的多态三核苷酸 (CAG) 重复区域进行基因分型。检测到三个等位基因（23、24和26个重复），等位基因频率随毛色的不同而不同。我们根据每只狗的主人回答的问卷，评估了 100 只黄褐色狗（54 只雄性和 46 只雌性）的性格特征。该问卷由五个子量表组成（社交性、嬉戏性、神经质、攻击性、注意力分散），并且基于子量表的内部一致性，心理测量特性是可以接受的。我们发现，具有短等位基因的雄性狗比具有较长等位基因的雄性狗具有更高的攻击性得分。相比之下，没有发现 AR 基因变异与女性性格之间存在关系的证据。据我们所知，我们的发现提供了 AR 基因多态性与犬类攻击性相关的第一个证据。
We tested for an association between variable number of tandem repeats in the canine androgen receptor (AR) gene and personality differences in Japanese Akita Inu dogs. The polymorphic trinucleotide (CAG) repeat region coding for glutamine in exon 1 of the AR gene was genotyped using genomic DNA obtained from 171 dogs. Three alleles (23, 24 and 26 repeats) were detected, and the allele frequency differed with the coat colour. We assessed the personality profiles of 100 fawn-coloured dogs (54 males and 46 females) based on a questionnaire answered by each dog's owner. The questionnaire consisted of five sub-scales (sociability, playfulness, neuroticism, aggressiveness, distractibility), and the psychometric properties were acceptable based upon internal consistency of the subscales. We found that male dogs with a short allele conferring increased AR function had higher aggressiveness scores than male dogs with longer alleles. By contrast, no evidence was found for a relationship between AR gene variants and personality in females. To our knowledge, our findings provide the first evidence of polymorphism in the AR gene being associated with canine aggression.