"Anatometabolic" tumor imaging: fusion of FDG PET with CT or MRI to localize foci of increased activity.
"Anatometabolic" tumor imaging: fusion of FDG PET with CT or MRI to localize foci of increased activity.
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发表时间：
1993-07
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通讯作者：
R. Wahl;L. Quint;Richard D. Cieslak;A. Aisen;R. Koeppe;C. Meyer
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作者：
R. Wahl;L. Quint;Richard D. Cieslak;A. Aisen;R. Koeppe;C. Meyer
当使用2-[18F]-氟-2-脱氧-d -葡萄糖（FDG）作为示踪剂时，内脏癌的正电子发射断层扫描（PET）图像通常被视为活性增加的“热点”，而正常解剖结构的可见性相对较低。我们描述了一种方法，通过该方法，计算机断层扫描或磁共振解剖图像可以在三维数字融合，使用刚性旋转平移比例模型与PET“代谢”图像，同时显示注册的解剖和代谢信息。这种“解剖代谢”融合图像在10例各种内脏癌患者中产生。在解剖和代谢研究中放置的外部基准标记，以及从重建传输图像上观察到的地标定义的内部解剖基准，用于实现图像融合。9例成功复位患者的基准配准平均误差幅度+/- s.e.m.为5.0 +/- 0.8 mm。在解剖研究和发射PET扫描（但未用于重新排列）上看到的已知解剖结构之间重新排列的平均精度为6.3 +/- 0.8 mm。通过这种方法，可以将FDG摄取增加的病灶定位到特定的解剖结构，这比仅从发射图像获得的基本解剖结构有了增强。使用这种合理简单的方法制作的解剖代谢融合图像应该在癌症和其他疾病患者的治疗中证明是有用的。
Positron emission tomographic (PET) images of visceral cancers are commonly visualized as "hot spots" of increased activity with relatively little normal anatomy discernable, when 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) is used as the tracer. We describe a method by which computed tomography or magnetic resonance anatomic images can be digitally fused in three dimensions, using a rigid rotate-translate scale model with PET "metabolic" images, to simultaneously display registered anatomic and metabolic information. Such "anatometabolic" fusion images were produced in 10 patients with a variety of visceral cancers. External fiducial markers placed during both the anatomic and the metabolic study, as well as internal anatomic fiducials defined from landmarks observed on reconstructed transmission images, were used to achieve image fusion. The mean error magnitude +/- s.e.m. of fiducial registration in the nine patients with successful realignments was 5.0 +/- 0.8 mm. The mean accuracy in realignment between known anatomic structures seen on both the anatomic study and on the emission PET scan (but not used in realignment) was 6.3 +/- 0.8 mm. Localization of foci of increased FDG uptake to specific anatomic structures was achieved by this method, which represented an enhancement over the rudimentary anatomy available from the emission images alone. Anatometabolic fusion images made using this reasonably simple method should prove useful in the management of patients with cancer and other diseases.