Long-term continuous-flow left ventricular assist devices (LVAD) as bridge to heart transplantation.
Long-term continuous-flow left ventricular assist devices (LVAD) as bridge to heart transplantation.
复制标题
长期连续流动左心室辅助装置（LVAD）作为心脏移植的桥梁。
作者：
M. Pozzi;R. Giraud;P. Tozzi;K. Bendjelid;J. Robin;P. Meyer;J. Obadia;C. Banfi
心脏移植（HTx）是终末期心力衰竭的治疗选择，但心脏供体的有限可用性仍然是一个主要问题。因此，长期机械循环支持（MCS）已被提出作为一种替代治疗方案，以帮助HTx等待名单上的患者在不同的时间段内将他们连接到心脏移植-所谓的移植桥（BTT）策略。目前，约90%的MCS患者接受左心室辅助装置（LVAD）。事实上，LVAD在过去十年中经历了多次改进，自2008年以来，连续流技术相对于脉动流技术的优势已经显而易见。本报告的目的是概述连续流LVAD在BTT策略特定环境中的应用，考虑到科学文献中最具代表性的文章，并重点关注连续流LVAD技术的演变、临床结局、对HTx策略的相关影响和未来前景。
Heart transplantation (HTx) is the treatment of choice for end-stage heart failure but the limited availability of heart's donors still represents a major issue. So long-term mechanical circulatory support (MCS) has been proposed as an alternative treatment option to assist patients scheduled on HTx waiting list bridging them for a variable time period to cardiac transplantation-the so-called bridge-to-transplantation (BTT) strategy. Nowadays approximately 90% of patients being considered for MCS receive a left ventricular assist device (LVAD). In fact, LVAD experienced several improvements in the last decade and the predominance of continuous-flow over pulsatile-flow technology has been evident since 2008. The aim of the present report is to give an overview of continuous-flow LVAD utilization in the specific setting of the BTT strategy taking into consideration the most representative articles of the scientific literature and focusing the attention on the evolution, clinical outcomes, relevant implications on the HTx strategy and future perspectives of the continuous-flow LVAD technology.
影响因子：
158.5
作者：
Rose, EA;Gelijns, AC;Meier, P
通讯作者：
Meier, P
预负荷诱导肌钙蛋白 I 降解，与心肌缺血无关。
影响因子：
37.8
作者：
Feng,J;Schaus,BJ;Fallavollita,JA;Lee,TC;CantyJr,JM
通讯作者：
CantyJr,JM