No-D NMR (No-Deuterium proton NMR) spectroscopy: A simple yet powerful method for analyzing reaction and reagent solutions
No-D NMR (No-Deuterium proton NMR) spectroscopy: A simple yet powerful method for analyzing reaction and reagent solutions
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DOI：
10.1021/ol049979
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发表时间：
2004-03-18
期刊：
影响因子：
5.2
通讯作者：
Yao, LJ
中科院分区：
文献类型：
--
作者：
Hoye, TR;Eklov, BM;Yao, LJ
该技术是一种直接监测或分析任何反应混合物或试剂溶液的简便而有效的方法。一些常见的过程（Fischer酯化，锂化，丁基锂/THF的兼容性，烯烃复分解，和定量分析），每个询问在其原生溶剂的例子，提出。光谱数据很容易获得，并且信息内容为No-D NMR光谱的常规使用提供了令人信服的理由。
The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, and a quantification assay), each interrogated in its native solvent, are presented. The spectral data are easy to acquire, and the information content makes a compelling case for routine use of No-D NMR spectroscopy.