Impairment of olfactory discrimination by blockade of GABA and nitric oxide activity in the honey bee antennal lobes.
Impairment of olfactory discrimination by blockade of GABA and nitric oxide activity in the honey bee antennal lobes.
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DOI：
10.1037/0735-7044.114.3.514
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发表时间：
2000
影响因子：
1.9
通讯作者：
J. Hosler;K. L. Buxton;B. H. Smith
中科院分区：
文献类型：
--
作者：
J. Hosler;K. L. Buxton;B. H. Smith
蜜蜂很容易将一种气味与蔗糖强化联系在一起，而这种反应由于结构上与条件气味相似而被推广到其他气味中。最近的研究表明，气味记忆的一部分集中在触角叶(AL)，在那里进行感觉信息的一级突触处理。AL和/或投射到其中的感觉传入显示一氧化氮合酶的染色模式，该酶催化气体递质一氧化氮(NO)的释放。结果表明，只有在条件化前阻止NO释放时，药物阻断NO释放才会削弱嗅觉辨别能力。阻断GABA能传递会破坏对相似但不同气味的识别，当阻断发生在条件或测试之前时就会这样做。这些结果表明，GABA和NO对联合嗅觉记忆在AL中的特异性具有调节作用。
Honey bees readily associate an odor with sucrose reinforcement, and the response generalizes to other odors as a function of structural similarity to the conditioned odor. Recent studies have shown that a portion of odor memory is consolidated in the antennal lobes (AL), where first-order synaptic processing of sensory information takes place. The AL and/or the sensory afferents that project into them show staining patterns for the enzyme nitric oxide synthase, which catalyzes the release of the gaseous transmitter nitric oxide (NO). The results show that pharmacological blockade of NO release impairs olfactory discrimination only when release is blocked before conditioning. Blockade of GABAergic transmission disrupts discrimination of similar but not dissimilar odorants, and does so when the block occurs before condition or before testing. These results show that GABA and NO regulate the specificity of associative olfactory memory in the AL.