Bandgap-Engineered Germanene Nanosheets as an Efficient Photodynamic Agent for Cancer Therapy
Bandgap-Engineered Germanene Nanosheets as an Efficient Photodynamic Agent for Cancer Therapy
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DOI：
10.1002/anie.202215795
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发表时间：
2023-02-14
影响因子：
16.6
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Ge, Min;Guo, Haiyan;Shi, Jianlin
二维（2D）单元素材料（Xenes）由于其独特的二维物理化学特性和单元素组成所带来的良好的生物安全性，在生物应用中显示出相当大的潜力。然而，Xenes的窄带隙阻碍了它们在生物传感器、生物成像和光治疗方面的广泛应用。在这项研究中，通过表面化学工程证明了以-H结尾的2D锗烯显示出1.65 eV的直接带隙，这使得该材料能够作为一种新型无机光敏剂用于单线态氧的光动力治疗。通过理论分析和体外研究，h -锗烯纳米片显示出显着扩大的带隙和良好的生物降解性，显示出实质性的癌症治疗能力。本研究证明了利用表面共价工程技术构建新型光动力治疗剂用于肿瘤催化治疗的可行性。
Two-dimensional (2D) monoelemental materials (Xenes) show considerable potential in bioapplications owing to their unique 2D physicochemical features and the favored biosafety resulting from their monoelemental composition. However, the narrow band gaps of Xenes prevent their broad applications in biosensors, bioimaging and phototherapeutics. In this study, it is demonstrated that 2D germanene terminated with -H via surface chemical engineering, shows a much broadened direct band gap of 1.65 eV, which enables the material to be used as a novel inorganic photosensitizer for the photodynamic therapy of singlet oxygen. Through theoretical analysis and in vitro studies, H-germanene nanosheets demonstrate a substantially enlarged band gap and favorable biodegradability, demonstrating a substantial cancer treatment capacity. This study demonstrates the feasibility of constructing novel therapeutic photodynamic agents by surface covalent engineering for catalytic tumor therapy.