Gastric H+ and HCO3- secretion in response to sham feeding in humans.
Gastric H+ and HCO3- secretion in response to sham feeding in humans.
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人类假喂养时的胃 H 和 HCO3- 分泌。
DOI：
10.1152/ajpgi.1985.248.2.g188
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Feldman,M
中科院分区：
文献类型：
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作者：
Feldman,M
假喂养（SF）用于评估生理迷走神经刺激对人类胃酸（H+）和碳酸氢盐（HCO3-）分泌以及顶叶和非顶叶体积分泌的影响。采用了一种最近经过验证的方法，该方法源自胃分泌的双成分模型。 SF 增加了壁细胞的 H+ 分泌（P 小于 0.001）和非壁细胞的 HCO3- 分泌（P 小于 0.01），尽管 H+ 反应更大、时间更长。阿托品不仅显着抑制 H+ 分泌，还显着抑制 HCO3- 和非顶叶体积分泌。 SF 期间 H+ 分泌峰值平均约为 27 mmol/h，而 HCO3- 分泌峰值平均约为 6 mmol/h。当静脉内五肽胃泌素输注已经最大限度地刺激了 H+ 分泌时，由于 HCO3- 中和 H+ 以及非顶叶分泌物稀释 H+，SF 实际上降低了胃液酸度和渗透压。因此，这些研究表明，SF 诱导的迷走神经刺激会增加人类 H+ 和 HCO3- 的分泌，并且该过程具有胆碱能依赖性。
Sham feeding (SF) was used to evaluate the effect of physiological vagal stimulation on gastric acid (H+) and bicarbonate (HCO3-) secretion in humans, as well as on parietal and nonparietal volume secretion. A recently validated method, derived from a two-component model of gastric secretion, was employed. SF increased both H+ secretion from parietal cells (P less than 0.001) and HCO3- secretion from nonparietal cells (P less than 0.01), although the H+ response was greater and more prolonged. Atropine significantly inhibited not only H+ secretion but also HCO3- and nonparietal volume secretion. Peak H+ secretion during SF averaged approximately 27 mmol/h, whereas peak HCO3- secretion averaged approximately 6 mmol/h. When H+ secretion was already maximally stimulated by an intravenous pentagastrin infusion, SF actually reduced gastric juice acidity and osmolality due to neutralization of H+ by HCO3- and to dilution of H+ by nonparietal secretions. These studies therefore indicate that vagal stimulation induced by SF increases both H+ and HCO3- secretion in humans and that this process is cholinergically dependent.