High Prevalence of Metabolic Syndrome in First-Degree Male Relatives of Women with Polycystic Ovary Syndrome Is Related to High Rates of Obesity
High Prevalence of Metabolic Syndrome in First-Degree Male Relatives of Women with Polycystic Ovary Syndrome Is Related to High Rates of Obesity
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DOI：
10.1210/jc.2009-1333
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发表时间：
2009-11-01
影响因子：
5.8
通讯作者：
Dunaif, Andrea
中科院分区：
文献类型：
--
作者：
Coviello, Andrea D.;Sam, Susan;Dunaif, Andrea
背景：与普通人群相比，患有多囊卵巢综合征 (PCOS) 的女性患代谢综合征 (MetS) 的风险是普通女性的两倍。受影响女性的母亲和姐妹的 MetS 患病率也有所增加。目的：本研究的目的是确定与一般人群中的男性相比，PCOS 女性的父亲和兄弟中 MetS 的患病率。设计和背景：我们在学术医疗中心进行了一项横断面观察性研究。参与者：总共对 211 名 PCOS 女性的父亲和 58 名兄弟进行了研究，并与 1153 名和 582 名第三次全国健康和营养调查进行比较(NHANES III) 年龄和种族/族裔相似的男性。主要结果测量：我们测量了 MetS 患病率。结果：与 NHANES III 男性相比，父亲（42% vs. 32%；P = 0.006）和兄弟（22% vs. 9%；P = 0.001）的 MetS 患病率有所增加。父亲和兄弟的体重指数（BMI）高于 NHANES III 男性（P < 0.0001）。调整 BMI 后，父亲和兄弟的 MetS 率与 NHANES III 组相似。父亲和兄弟的总睾酮水平与 MetS 呈负相关，但这种关系也可以通过男性亲属较高的 BMI 来解释。 结论：与 NHANES III 的美国一般男性人群相比，PCOS 女性的男性亲属的 MetS 和肥胖患病率更高。与患有 PCOS 的女性及其女性亲属相比，男性亲属中 MetS 的患病率较高，这是由于 BMI 升高所致。这些研究结果表明，多囊卵巢综合症女性男性亲属的代谢综合征发生率高于一般人群，与肥胖率较高有关。 (临床内分泌代谢杂志 94: 4361-4366, 2009)
Context: Women with polycystic ovary syndrome (PCOS) have twice the risk for metabolic syndrome (MetS) compared to women from the general population. Mothers and sisters of affected women also have an increased prevalence of MetS.Objective: The aim of the study was to determine the prevalence of MetS in fathers and brothers of women with PCOS compared to men from the general population.Design and Setting: We conducted a cross-sectional observational study at academic medical centers.Participants: A total of 211 fathers and 58 brothers of women with PCOS were studied and compared to 1153 and 582 Third National Health and Nutrition Survey (NHANES III) men of similar age and race/ethnicity, respectively.Main Outcome Measure: We measured MetS prevalence.Results: The prevalence of MetS was increased in fathers (42 vs. 32%; P = 0.006) and brothers (22 vs. 9%; P = 0.001) compared to NHANES III men. Fathers and brothers had higher body mass index (BMI) than NHANES III men(P < 0.0001). MetS rates were similar in fathers and brothers compared to NHANES III groups after adjusting for BMI. Total testosterone was inversely related to MetS in both fathers and brothers, but this relationship was also accounted for by the higher BMI in male relatives.Conclusion: Male relatives of women with PCOS had increased prevalence rates of MetS and obesity compared to the general U. S. male population from NHANES III. In contrast to women with PCOS and their female relatives, the higher prevalence of MetS in male relatives was accounted for by elevated BMI. These findings suggest that the high rates of MetS in male relatives of women with PCOS are related to higher rates of obesity than the general population. (J Clin Endocrinol Metab 94: 4361-4366, 2009)