Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester pools
Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester pools
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DOI：
10.1017/s0007114511000377
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发表时间：
2011-08-28
影响因子：
3.6
通讯作者：
Burdge, Graham C.
中科院分区：
文献类型：
--
作者：
Lewis, Rohan M.;Hanson, Mark A.;Burdge, Graham C.
发育中的胎儿需要充足的脂肪酸供应，特别是多不饱和脂肪酸，以实现最佳生长和发育。关于脂肪酸通过胎盘转移到胎儿循环中的情况知之甚少。然而，脂肪酸转移到胎儿循环中的分子形式可能会影响它们的代谢，从而影响它们对特定组织的可用性。本研究的目的是通过比较脐静脉（LW）和脐动脉（UA）血浆中各个脂质池的脂肪酸组成，确定胎儿循环中的哪些脂质池富含来自胎盘的脂肪酸。十个无并发症的妊娠在分娩后收集了来自 UV 和 UA 的血浆，并通过 GC 测定了每种脂质类别的脂肪酸组成。由于 16:0、16:1 n-7、18:1n-9、18:n-7、18:2n-6、20:3n-6、20:4n-6、24:0 和 22:6n-3 中的富集，UV 中的总 NEFA 浓度是 UA 中的两倍 (P < 0.05)。由于 16:0 的富集，UV 中的总胆固醇酯浓度是 UA 中的两倍 (P < 0.05)。 16: 1n-7、18: 0、18: 1n-9、18:1n-7、18: 2n-6 和 20: 4n-6。 TAG 或磷脂酰胆碱的总浓度或组成没有显着的 UV-UA 差异。本研究表明，脂肪酸在胎盘中差异富集到胎儿循环中的特定脂质池中。这种分配可以促进将单独的脂肪酸供应到特定的胎儿组织。
The developing fetus requires an adequate supply of fatty acids, in particular PUFA, for optimal growth and development. Little is known about the transfer of fatty acids by the placenta into the fetal circulation. However, the molecular form in which fatty acids are transferred into the fetal circulation may influence their metabolism and hence their availability to specific tissues. The aim of the present study was to determine which lipid pools in the fetal circulation become enriched in fatty acids from the placenta by comparing the fatty acid compositions of individual lipid pools between umbilical venous (LW) and umbilical arterial (UA) plasma. Plasma from the UV and UA was collected after delivery from ten uncomplicated pregnancies, and the fatty acid composition of each lipid class was determined by GC. Total NEFA concentration in the UV was twofold higher than in the UA (P < 0.05) due to enrichment in 16 : 0, 16:1 n-7, 18 :1n-9, 18: n-7, 18: 2n-6, 20 : 3n-6, 20 :4n-6, 24 :0 and 22: 6n-3. Total cholesteryl ester concentration was twofold higher in the UV than in the UA (P < 0.05) due to enrichment in 16 :0. 16: 1n-7, 18 : 0, 18: 1n-9, 18 :1n-7, 18: 2n-6 and 20 : 4n-6. There were no significant UV-UA differences in the total concentration or composition of TAG or phosphatidylcholine. The present study demonstrates differential enrichment across the placenta of fatty acids into specific lipid pools in the fetal circulation. Such partitioning may facilitate supply of individual fatty acids to specific fetal tissues.