Asymmetric synthesis of deoxypolypropionate units via stereoselective hydrogenation of optically active cycloheptatriene.
Asymmetric synthesis of deoxypolypropionate units via stereoselective hydrogenation of optically active cycloheptatriene.
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DOI：
10.1021/ol0483596
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发表时间：
2004-10
期刊：
影响因子：
5.2
通讯作者：
T. Sugimura;Yasuhiro Sato;Chun Young Im;T. Okuyama
中科院分区：
文献类型：
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作者：
T. Sugimura;Yasuhiro Sato;Chun Young Im;T. Okuyama
以3，5-二甲基苯酚为原料，经9-11步反应合成了光学活性聚丙酸酯单元。该序列由手性2，4-戊二醇系链控制的Buchner反应和在Raney镍上的非对映选择性氢化组成。[反应：见正文]
Optically active polypropionate units were synthesized in 9-11 steps from 3,5-dimethylphenol. The sequence consists of the Buchner reaction controlled by a chiral 2,4-pentanediol tether and diastereoselective hydrogenation over Raney nickel. [reaction: see text]