RETINOIC ACID INDUCES 3 NEWLY CLONED HOXA1 TRANSCRIPTS IN MCF7 BREAST-CANCER CELLS
RETINOIC ACID INDUCES 3 NEWLY CLONED HOXA1 TRANSCRIPTS IN MCF7 BREAST-CANCER CELLS
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DOI：
10.1006/bbrc.1995.2522
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发表时间：
1995-10-13
影响因子：
3.1
通讯作者：
CASTRONOVO, V
中科院分区：
文献类型：
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作者：
CHARIOT, A;MOREAU, L;CASTRONOVO, V
参与发育、分化和恶性转化的基因的协调表达受包括含同源结构域的蛋白质的转录因子调节。然而，它们的大部分cDNA序列仍然是未知的。我们在这里报告的三个新克隆的HOXA 1转录人乳腺癌细胞的分子特征。此外，我们提供的证据表明，这些选择性剪接转录编码一个同源结构域的蛋白质和两个产品缺乏保守的DNA结合结构域。此外，我们证明，所有三个HOXA 1转录诱导的视黄酸在MCF 7细胞。综上所述，我们的研究结果表明HOXA 1基因可能是乳腺癌细胞表型建立的关键因素。(C)出版社：Academic Press
Coordinated expression of genes involved in development, differentiation and malignant transformation is regulated by transcription factors including homeodomain-containing proteins. However, most of their cDNA sequences are still unknown. We report here the molecular characterization of three newly cloned HOXA1 transcripts from human breast cancer cells. In addition, we provide evidence that these alternatively spliced transcripts encode one homeodomain-containing protein and two products lacking the conserved DNA-binding domain. Moreover, we demonstrate that all three HOXA1 transcripts are induced by retinoic acid in MCF7 cells. Taken together, our results suggest that HOXA1 gene may be a key element in the establishment of the breast cancer cell phenotype. (C) 1995 Academic Press, Inc.