Changes in the fluid volume balance between intra- and extracellular water in a sample of Japanese adults aged 15-88 yr old: a cross-sectional study
Changes in the fluid volume balance between intra- and extracellular water in a sample of Japanese adults aged 15-88 yr old: a cross-sectional study
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DOI：
10.1152/ajprenal.00477.2017
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发表时间：
2018-04-01
影响因子：
4.2
通讯作者：
Sakai, Ken
中科院分区：
文献类型：
--
作者：
Ohashi, Yasushi;Joki, Nobuhiko;Sakai, Ken
细胞内水（ICW）和细胞外水（ECW）之间的液体体积平衡随着年龄和各种医疗条件而逐渐改变。了解这些生理变化将有助于临床决策相关的体液评估。2014年，共有1992人（753名男性和1239名女性）参加了这项研究，年龄在bb0 = 15岁，他们在训练馆进行了身体成分测量。我们开发了一个回归公式来评估这些受试者中年龄与ECW / ICW比值的关系。男性和女性的平均年龄分别为51.2 +/- 15.2岁和57.4 +/- 15.2岁，平均体重指数分别为23.4 +/- 3.3和21.1 +/- 2.8 kg/m(2)。男性和女性受试者的体液总容量分别为39.6 +/- 4.9和27.7 +/- 3.0 l，体脂质量占每千克体重的百分比分别为19%和26%。ECW/ICW比值随着年龄的增长而增加，因为ICW含量的下降幅度大于ECW含量的下降幅度，尤其是在70岁以后。计算年龄调整后ECW/ICW比值的回归公式为：男性为0.5857 + 7.4334 Chi 10(-6) X (age)(2)，女性为0.6062 + 5.5775 Chi 10(-6) Chi (age)(2)。综上所述，ICW和ECW含量之间的体液失衡是由细胞体积减少和衰老以及肌肉衰减引起的。因此，我们提出的公式可以作为计算体液成分的有用评估工具。
The fluid volume balance between intracellular water (ICW) and extracellular water (ECW) gradually changes with age and various medical conditions. Comprehension of these physiological changes would aid in clinical decision-making related to body fluid assessments. A total of 1,992 individuals (753 men and 1,239 women) aged >= 15 yr included in this study had their body composition measurements performed at training gyms in 2014. We developed a regression formula to assess the association of age with the ratio of ECW to ICW in these subjects. The mean ages of male and female subjects were 51.2 +/- 15.2 and 57.4 +/- 15.2 yr, and their mean body mass indexes were 23.4 +/- 3.3 and 21.1 +/- 2.8 kg/m(2), respectively. The total fluid volumes of male and female subjects were 39.6 +/- 4.9 and 27.7 +/- 3.0 liters, whereas the percent body fat mass per kilogram of body weight were 19 and 26%, respectively. The ECW-to-ICW ratio increased with age because of the steeper decrease in the ICW content than in the ECW content, especially after the age of 70 yr. The regression formulas used for calculating the age-adjusted ECW/ICW ratio were as follows: 0.5857 + 7.4334 Chi 10(-6) X (age)(2) in men and 0.6062 + 5.5775 Chi 10(-6) Chi (age)(2) in women. In conclusion, the fluid imbalance between ICW and ECW contents is driven by decreased cell volume associated with aging and muscle attenuation. Therefore, our proposed formula may serve as a useful assessment tool for the calculation of body fluid composition.