Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis
Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis
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DOI：
10.1016/j.jvs.2010.03.017
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发表时间：
2010-08-01
影响因子：
4.3
通讯作者：
Hamano, Kimikazu
中科院分区：
文献类型：
--
作者：
Kubo, Masayuki;Li, Tao-Sheng;Hamano, Kimikazu
目的：虽然继发性淋巴水肿是癌症手术和放射治疗后的常见并发症，但淋巴水肿的治疗选择仍然有限，而且大多无效。因此，我们研究了体外冲击波治疗在促进淋巴管生成和改善继发性淋巴水肿方面的作用。方法：通过阻断淋巴管建立兔耳淋巴水肿模型。术后2周，分别给予或不给予低能量冲击波(0.09mJ/mm(2)，200次)治疗，每周3次，共4周。结果：Western印迹分析显示血管内皮生长因子-C的表达是对照组的1.23倍(P
Objective: Although secondary lymphedema is a common complication after surgical and radiation therapy for cancer, the treatment options for lymphedema remain limited and largely ineffective. We thus studied the effect of extracorporeal shock wave therapy on promoting lymphangiogenesis and improving secondary lymphedema.Methods: A rabbit ear model of lymphedema was created by disruption of lymphatic vessels. Two weeks after surgery, the lymphedematous ear was treated with or without low-energy shock waves (0.09 mJ/mm(2), 200 shots), three times per week for 4 weeks.Results: Western blot analysis showed that the expression of vascular endothelial growth factor (VEGF)-C (1.23-fold, P