Assembly of Indoline-2-carboxylate-Embodied Dipeptides via Pd-Catalyzed C(sp2)-H Bond Direct Functionalization
Assembly of Indoline-2-carboxylate-Embodied Dipeptides via Pd-Catalyzed C(sp2)-H Bond Direct Functionalization
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DOI：
10.1021/ol503514t
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发表时间：
2015-02-06
期刊：
影响因子：
5.2
通讯作者：
Ma, Dawei
中科院分区：
文献类型：
--
作者：
He, Yu-Peng;Zhang, Chao;Ma, Dawei
在1-氟-2，4，6-三甲基吡啶四氟硼酸盐存在下，2-甲氧基亚氨基酰基保护的苯丙氨酸衍生物在Pd（OAc）（2）催化下于110 ℃进行分子内环化反应，得到取代的吲哚啉-2-羧酸酯，其通过Raney Ni催化氢化转化为吲哚啉-2-羧酸酯体现的二肽。
Intramolecular dehydrogenative cyclization of 2-methoxyiminoacyl-protected phenylalanine derivatives proceeded at 110 degrees C under catalysis of Pd(OAc)(2) in the presence of 1-fluoro-2,4,6-trimethylpyridinium tetrafluoroborate to afford substituted indoline-2-carboxylates that were converted into indoline-2-carboxylate-embodied dipeptides via Raney Ni-catalyzed hydrogenation.